1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  2. Microtubule/Tubulin
    Apoptosis
  3. Cryptophycin 1

Cryptophycin 1 (Synonyms: Cryptophycin A)

Cat. No.: HY-136294
Handling Instructions

Cryptophycin 1 is a potent cytotoxic antimicrotubule agent which is isolated from Nostoc sp. Cryptophycin 1 can induce cells apoptosis, and exhibits antitumor activity and exceptional antiproliferative potency.

For research use only. We do not sell to patients.

Cryptophycin 1 Chemical Structure

Cryptophycin 1 Chemical Structure

CAS No. : 124689-65-2

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Description

Cryptophycin 1 is a potent cytotoxic antimicrotubule agent which is isolated from Nostoc sp. Cryptophycin 1 can induce cells apoptosis, and exhibits antitumor activity and exceptional antiproliferative potency[1][2][3].

In Vitro

Cryptophycin 1 (50 pM) rapidly causes morphological changes consistent with the induction of apoptosis in SKOV3 and MDA-MB-435 cells[1].
Cryptophycin 1 (50 pM; 12-24 h) causes an accumulation of MDA-MB-435 cells in G2/M[1].
Cryptophycin 1 (100 nM; 1-7 min) markedly reduces the rates and extents of microtubule shortening and growing events and dramatically increases the duration of phases of attenuation or pause[2].

Apoptosis Analysis[1]

Cell Line: SKOV3 cells
Concentration: 50 pM
Incubation Time: 4 hours
Result: Caused rapid cell shrinkage, loss of the normal elliptical spheroid shape and the formation of membrane blebs.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-435 cells
Concentration: 50 pM
Incubation Time: 12, 18, 24 hours
Result: A doubling in the number of cells in G2/M at 12 hr.
Still a large number of cells (58%) in G2/M at 18 hr.
In Vivo

Cryptophycin 1 (i.v.) exhibits anti-tumor activity in mice[3].

Molecular Weight

655.18

Formula

C₃₅H₄₃ClN₂O₈

CAS No.

124689-65-2

SMILES

C[[email protected]@H]([[email protected]@](C/C=C/C(N[[email protected]@H]1CC(C=C2)=CC(Cl)=C2OC)=O)([H])OC([[email protected]@H](OC([[email protected]@H](CNC1=O)C)=O)CC(C)C)=O)[[email protected]]3([H])[[email protected]](C4=CC=CC=C4)([H])O3

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Cryptophycin 1Cryptophycin ACryptophycin1Cryptophycin-1Microtubule/TubulinApoptosiscytotoxicantimicrotubuleapoptosisantitumorantiproliferativeInhibitorinhibitorinhibit

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Product Name:
Cryptophycin 1
Cat. No.:
HY-136294
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