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  4. Curcumin-β-D-glucuronide

Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer.

For research use only. We do not sell to patients.

Curcumin-β-D-glucuronide Chemical Structure

Curcumin-β-D-glucuronide Chemical Structure

CAS No. : 227466-72-0

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5 mg USD 580 In-stock
10 mg USD 1050 In-stock
25 mg USD 2250 In-stock
50 mg USD 3600 In-stock
100 mg USD 5800 In-stock
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Based on 1 publication(s) in Google Scholar

Curcumin-β-D-glucuronide Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer[1][2].

In Vivo

Curcumin-β-D-glucuronide (90 mg/kg; i.p. thrice a week for 3 weeks) exhibit potent anti-tumor effects on KRASm/TP53w HCT116 xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c/AnNCr j‐nu/nude mice (6 weeks) were transplanted KRASm/TP53w HCT116 cells[1]
Dosage: 90 mg/kg
Administration: I.p. thrice a week for 3 weeks
Result: Suppressed tumor growth by 38%.
Did not show a negative impact on body weight.
Attenuated NF‐κB activity.
Molecular Weight

544.50

Formula

C27H28O12
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

COC(C=C(C=C1)/C=C/C(CC(/C=C/C2=CC(OC)=C(C=C2)O)=O)=O)=C1O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (91.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8365 mL 9.1827 mL 18.3655 mL
5 mM 0.3673 mL 1.8365 mL 3.6731 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8365 mL 9.1827 mL 18.3655 mL 45.9137 mL
5 mM 0.3673 mL 1.8365 mL 3.6731 mL 9.1827 mL
10 mM 0.1837 mL 0.9183 mL 1.8365 mL 4.5914 mL
15 mM 0.1224 mL 0.6122 mL 1.2244 mL 3.0609 mL
20 mM 0.0918 mL 0.4591 mL 0.9183 mL 2.2957 mL
25 mM 0.0735 mL 0.3673 mL 0.7346 mL 1.8365 mL
30 mM 0.0612 mL 0.3061 mL 0.6122 mL 1.5305 mL
40 mM 0.0459 mL 0.2296 mL 0.4591 mL 1.1478 mL
50 mM 0.0367 mL 0.1837 mL 0.3673 mL 0.9183 mL
60 mM 0.0306 mL 0.1530 mL 0.3061 mL 0.7652 mL
80 mM 0.0230 mL 0.1148 mL 0.2296 mL 0.5739 mL
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Curcumin-β-D-glucuronide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Curcumin-β-D-glucuronide227466-72-0OthersCurcumincoloncancerInhibitorinhibitorinhibit

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