1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase
  3. Curzerene

Curzerene 

Cat. No.: HY-N1963
Handling Instructions

Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis.

For research use only. We do not sell to patients.

Curzerene Chemical Structure

Curzerene Chemical Structure

CAS No. : 17910-09-7

Size Price Stock
5 mg USD 119 Ask For Quote & Lead Time
10 mg USD 202 Ask For Quote & Lead Time
20 mg USD 343 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis[1].

IC50 & Target

GSTA1[1]

In Vitro

Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively[1].
Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells[1].
Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose[1].
Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells[1].
Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells[1].

Cell Viability Assay[1]

Cell Line: SPC-A1 cells
Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro.

Apoptosis Analysis[1]

Cell Line: SPC-A1 cells
Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM
Incubation Time: 48 hours
Result: Induced apoptosis of the cells in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: SPC-A1 cells
Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM
Incubation Time: 48 hours
Result: Induced G2/M cell cycle arrest of SPC A1 cells.

RT-PCR[1]

Cell Line: SPC-A1 cells
Concentration: 6.25 µM, 25 µM, 100 µM
Incubation Time: 48 hours
Result: Decreased GSTA1 mRNA expression.
Molecular Weight

216.32

Formula

C₁₅H₂₀O

CAS No.

17910-09-7

SMILES

C=C([[email protected]]([[email protected]@](C)(C=C)C1)CC2=C1OC=C2C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1155.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6228 mL 23.1139 mL 46.2278 mL
5 mM 0.9246 mL 4.6228 mL 9.2456 mL
10 mM 0.4623 mL 2.3114 mL 4.6228 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (28.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (28.89 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CurzereneGutathione S-transferaseGlutathione transferasesGSTsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Curzerene
Cat. No.:
HY-N1963
Quantity:
MCE Japan Authorized Agent: