1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase
  3. Curzerene

Curzerene 

Cat. No.: HY-N1963 Purity: >97.0%
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Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis.

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Curzerene Chemical Structure

Curzerene Chemical Structure

CAS No. : 17910-09-7

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5 mg USD 119 In-stock
Estimated Time of Arrival: December 31
10 mg USD 202 In-stock
Estimated Time of Arrival: December 31
20 mg USD 343 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis[1].

IC50 & Target

GSTA1[1]

In Vitro

Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively[1].
Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells[1].
Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose[1].
Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells[1].
Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells[1].

Cell Viability Assay[1]

Cell Line: SPC-A1 cells
Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro.

Apoptosis Analysis[1]

Cell Line: SPC-A1 cells
Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM
Incubation Time: 48 hours
Result: Induced apoptosis of the cells in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: SPC-A1 cells
Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM
Incubation Time: 48 hours
Result: Induced G2/M cell cycle arrest of SPC A1 cells.

RT-PCR[1]

Cell Line: SPC-A1 cells
Concentration: 6.25 µM, 25 µM, 100 µM
Incubation Time: 48 hours
Result: Decreased GSTA1 mRNA expression.
Molecular Weight

216.32

Formula

C₁₅H₂₀O

CAS No.

17910-09-7

SMILES

C=C([[email protected]]([[email protected]@](C)(C=C)C1)CC2=C1OC=C2C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (231.14 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6228 mL 23.1139 mL 46.2278 mL
5 mM 0.9246 mL 4.6228 mL 9.2456 mL
10 mM 0.4623 mL 2.3114 mL 4.6228 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (11.56 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.56 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CurzereneGutathione S-transferaseGlutathione transferasesGSTsInhibitorinhibitorinhibit

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Curzerene
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HY-N1963
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