1. Cytokines
  2. Recombinant Human Amphiregulin (HEK293-expressed)

Recombinant Human Amphiregulin (HEK293-expressed)

Cat. No.: HY-P7002
Handling Instructions

Recombinant Human Amphiregulin (HEK293-expressed) is an EGF receptor (EGFR) ligand, and essential for epithelial development in various organs.

For research use only. We do not sell to patients.

Cytokines-MedChemExpress
Size Price Stock Quantity
10 μg $80 In-stock
Estimated Time of Arrival: December 31
50 μg $190 In-stock
Estimated Time of Arrival: December 31
100 μg $290 In-stock
Estimated Time of Arrival: December 31
250 μg   Get quote  

* Please select Quantity before adding items.

  • Technical Parameters

  • Properties

  • Description

Synonyms
rHuAmphiregulin; AR; AREG; Colorectum cell-derived growth factor; CRDGF
Species

Human

Source

HEK 293

Accession

P15514

Gene ID

374

Molecular Weight

15-20 kDa

AA Sequence

SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK

Biological Activity
The ED50 is <0.2 ng/mL as measured by 3T3 cells.
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against PBS.

Endotoxin Level

<0.2 EU/μg, determined by LAL method.

Reconsititution

Reconstitute the lyophilized recombinant Human Amphiregulin (HEK293-expressed) (rHuAmphiregulin) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability

Lyophilized recombinant Human Amphiregulin (HEK293-expressed) (rHuAmphiregulin) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

Amphiregulin, an EGF receptor (EGFR) ligand, and essential for epithelial development in various organs. Amphiregulin is suggested to act as a protective factor in a liver injury model. In mice model with bleomycin-induced pneumopathy, Recombinant Human Amphiregulin improves the survival rate and suppresses the degrees of inflammation and fibrosis and the number of TUNEL-positive cells in lung tissues. Recombinant Human Amphiregulin treatment enhances the activation of Akt and Erk in lung epithelial cells[1].

Documentation
References
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The dilution calculator equation

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Product Name:
Recombinant Human Amphiregulin (HEK293-expressed)
Cat. No.:
HY-P7002
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