2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. DBCO-PEG4-GGFG-Exatecan

DBCO-PEG4-GGFG-Exatecan  (Synonyms: DBCO-PEG4-GGFG-DX8951)

Cat. No.: HY-134723 Purity: 98.64%
COA Handling Instructions

DBCO-PEG4-GGFG-Exatecan (DBCO-PEG4-GGFG-DX8951) is a agent-linker conjugate for ADC with potent antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the cleavable ADC linker DBCO-PEG4-GGFG.

For research use only. We do not sell to patients.

DBCO-PEG4-GGFG-Exatecan Chemical Structure

DBCO-PEG4-GGFG-Exatecan Chemical Structure

CAS No. : 2694856-51-2

Size Price Stock Quantity
5 mg USD 850 In-stock
10 mg USD 1450 In-stock
25 mg USD 2800 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

DBCO-PEG4-GGFG-Exatecan Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

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  • References

  • Customer Review

Description

DBCO-PEG4-GGFG-Exatecan (DBCO-PEG4-GGFG-DX8951) is a agent-linker conjugate for ADC with potent antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the cleavable ADC linker DBCO-PEG4-GGFG[1].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linke[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-PEG4-GGFG-Exatecan Related Antibodies
Molecular Weight

1375.45

Appearance

Solid

Formula

C72H79FN10O17
CAS No.
SMILES

O=C1OCC2=C(C=C(C3=NC4=CC(F)=C(C)C(CC[C@@H]5NC(COCNC(CNC([C@H](CC6=CC=CC=C6)NC(CNC(CNC(CCOCCOCCOCCOCCNC(CCC(N7C8=CC=CC=C8C#CC9=CC=CC=C9C7)=O)=O)=O)=O)=O)=O)=O)=O)=C4C5=C3C%10)N%10C2=O)[C@]1(CC)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (36.35 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7270 mL 3.6352 mL 7.2703 mL
5 mM 0.1454 mL 0.7270 mL 1.4541 mL
10 mM 0.0727 mL 0.3635 mL 0.7270 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.82 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (1.82 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (1.82 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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DBCO-PEG4-GGFG-Exatecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DBCO-PEG4-GGFG-Exatecan2694856-51-2DBCO-PEG4-GGFG-DX8951Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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