1. Metabolic Enzyme/Protease
  2. Thrombin
  3. Desirudin

Desirudin (Synonyms: CGP 39393; Revasc)

Cat. No.: HY-109549
Handling Instructions

Desirudin (CGP 39393) is a thrombin inhibitor. Desirudin can inhibit the formation of blood clots and venous stasis thrombosis, which is used for the research of thrombocytopenia or platelet dysfunction.

For research use only. We do not sell to patients.

Desirudin Chemical Structure

Desirudin Chemical Structure

CAS No. : 120993-53-5

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Description

Desirudin (CGP 39393) is a thrombin inhibitor. Desirudin can inhibit the formation of blood clots and venous stasis thrombosis, which is used for the research of thrombocytopenia or platelet dysfunction[1][2].

IC50 & Target

ED50: 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.)[2].

In Vivo

Desirudin (CGP 39393, 0.75-3.0 mg/kg, a bolus plus infusion administration, dogs model of cardiopulmonary bypass) is effective in Inhibiting clot formation[1].
Desirudin (0.01-1 mg/kg, Intravenous injections and subcutaneous injection, rat shunt model) inhibits thrombus development with ED50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.), and inhibits venous stasis thrombosis with ED50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mongrel dogs model of cardiopulmonary bypass[1]
Dosage: 1.0 mg/kg + 0.75 mg/kg/h, 1.0 mg/kg + 1.50 mg/kg/h, 1.0 mg/kg + 2.25 mg/kg/h, 1.0 mg/kg + 3.0 mg/kg/h.
Administration: Administered as a bolus plus infusion
Result: Inhibited clot formation with no adverse hemodynamic or hematologic effects.
Animal Model: Rat shunt model of thrombus formation on a cotton-thread[2]
Dosage: 0.01-1 mg/kg approximately
Administration: Intravenous injections, subcutaneous injection
Result: Inhibited thrombus development with ED50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.).
Inhibited venous stasis thrombosis with ED50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.).
CAS No.
SMILES

[desirudin]

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Desirudin
Cat. No.:
HY-109549
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