1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. Dexpramipexole dihydrochloride

Dexpramipexole dihydrochloride  (Synonyms: (R)-Pramipexole dihydrochloride; R-(+)-Pramipexole dihydrochloride; KNS-760704 dihydrochloride)

Cat. No.: HY-17355A Purity: 99.71%
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Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and weak non-ergoline dopamine agonist.

For research use only. We do not sell to patients.

Dexpramipexole dihydrochloride Chemical Structure

Dexpramipexole dihydrochloride Chemical Structure

CAS No. : 104632-27-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 61 In-stock
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid
5 mg USD 56 In-stock
10 mg USD 90 In-stock
25 mg USD 190 In-stock
50 mg USD 320 In-stock
100 mg USD 480 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Dexpramipexole dihydrochloride:

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Dexpramipexole dihydrochloride

IF

    Dexpramipexole dihydrochloride purchased from MedChemExpress. Usage Cited in: Neuroreport. 2023 Jan 23.  [Abstract]

    Dexpramipexole (DPX; 3 mg/kg; i.p.; once daily for 6 consecutive days) attenuates the LPS-induced increase in the number of TUNEL-positive cells in the hippocampus in SAE mice.

    Dexpramipexole dihydrochloride purchased from MedChemExpress. Usage Cited in: Neuroreport. 2023 Jan 23.  [Abstract]

    Dexpramipexole (DPX; 3 mg/kg; i.p.; once daily for 6 consecutive days) attenuates LPS-induced activation of microglia and astrocytes in the hippocampus in SAE mice. (a) Representative images of Iba-1 staining and quantification of Iba-1 (green) fluorescence intensity in the hippocampal CA1 and DG regions. (b) Representative images of GFAP staining and quantification of GFAP (red) fluorescence intensity in the hippocampal CA1 and DG regions. DAPI staining is shown in blue.
    • Biological Activity

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    • Customer Review

    Description

    Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and weak non-ergoline dopamine agonist.

    In Vitro

    Dexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    284.25

    Formula

    C10H19Cl2N3S

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NC(S1)=NC2=C1C[C@H](NCCC)CC2.[H]Cl.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (351.80 mM)

    H2O : 100 mg/mL (351.80 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5180 mL 17.5902 mL 35.1803 mL
    5 mM 0.7036 mL 3.5180 mL 7.0361 mL
    10 mM 0.3518 mL 1.7590 mL 3.5180 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (351.80 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.71%

    References
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    Dexpramipexole dihydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Dexpramipexole dihydrochloride
    Cat. No.:
    HY-17355A
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