Dictyostatin  (Synonyms: (-)-Dictyostatin; Dictyostatin 1)

Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizing agent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies^[1][2][3].

Dictyostatin (0-100 nM; 72-120 h) shows antiproliferative activity in cancer cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dictyostatin (0.3, 1 mg/kg; i.p.; once-weekly for 3 months) improves MT density and reduced axonal dystrophy in mouse^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

532.75

C₃₂H₅₂O₆

156312-07-1

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• [1]. George R. Pettit, et al. Isolation and structure of the cancer cell growth inhibitor dictyostatin 1. J. Chem. Soc., Chem. Commun., 1995, 2373-2670.

  [2]. Vollmer LL, et al. A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos. Mol Cancer Ther. 2011 Jun;10(6):994-1006.  [Content Brief]

  [3]. Makani V, et al. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta Neuropathol Commun. 2016 Sep 29;4(1):106.  [Content Brief]