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Diphtheria toxin CRM197 

Cat. No.: HY-P1976
Handling Instructions

Diphtheria toxin CRM197, a nontoxic variant of diphtheria toxin, has a single mutation (Glycine to Glutamate substitution at position 52) that eliminates its toxicity. CRM197 is widely used as a carrier protein in conjugate vaccines.

For research use only. We do not sell to patients.

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Diphtheria toxin CRM197 Chemical Structure

Diphtheria toxin CRM197 Chemical Structure

CAS No. : 92092-36-9

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Description

Diphtheria toxin CRM197, a nontoxic variant of diphtheria toxin, has a single mutation (Glycine to Glutamate substitution at position 52) that eliminates its toxicity. CRM197 is widely used as a carrier protein in conjugate vaccines[1].

In Vitro

Diphtheria toxin CRM197 is an enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid substitution (G52E). Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against encapsulated bacteria and is currently used to vaccinate children globally against Haemophilus influenzae, pneumococcus, and meningococcus[1][2].
Diphtheria toxin, a single polypeptide secreted by lysogenic strains of Corynebacterium diphtheria, causes the disease diphtheria in humans by gaining entry into the cytoplasm of cells and inhibiting protein synthesis[3][4].

CAS No.

92092-36-9

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Diphtheria toxin CRM197Diphtheria toxin CRM 197Diphtheria toxin CRM-197OthersexotoxinvirulencefactortoxigenicdiphtheriamyocarditissynthesisInhibitorinhibitorinhibit

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Diphtheria toxin CRM197
Cat. No.:
HY-P1976
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