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  3. DL001

DL001 

Cat. No.: HY-126243
Handling Instructions

DL001, a FKBP12-dependent rapamycin analog, is a selective mechanistic Target Of Rapamycin Complex 1 (mTORC1) inhibitor with an IC50 of 74.9 pM. In cells, DL001 efficiently represses elevated mTORC1 activity and restores normal gene expression to cells lacking a functional tuberous sclerosis complex. DL001 inhibits mTORC1 signaling without impairing glucose homeostasis and with substantially reduced and no side effects on lipid metabolism and the immune system in vivo in C57BL/6J mice.

For research use only. We do not sell to patients.

DL001 Chemical Structure

DL001 Chemical Structure

CAS No. : 909387-87-7

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Description

DL001, a FKBP12-dependent rapamycin analog, is a selective mechanistic Target Of Rapamycin Complex 1 (mTORC1) inhibitor with an IC50 of 74.9 pM. In cells, DL001 efficiently represses elevated mTORC1 activity and restores normal gene expression to cells lacking a functional tuberous sclerosis complex. DL001 inhibits mTORC1 signaling without impairing glucose homeostasis and with substantially reduced and no side effects on lipid metabolism and the immune system in vivo in C57BL/6J mice[1].

IC50 & Target[1]

mTORC1

74.9 pM (IC50)

Molecular Weight

870.12

Formula

C₄₉H₇₅NO₁₂

CAS No.

909387-87-7

SMILES
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Please store the product under the recommended conditions in the Certificate of Analysis.

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DL001
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