1. Membrane Transporter/Ion Channel
  2. URAT1
  3. Dotinurad

Dotinurad 

Cat. No.: HY-109031 Purity: 98.10%
Handling Instructions

Dotinurad is a potent and selective urate reabsorption inhibitor. Dotinurad inhibits urate transporter 1 (URAT1) with an IC50 value of 37.2 nM. Dotinurad acts as a uricosuric agent.

For research use only. We do not sell to patients.

Dotinurad Chemical Structure

Dotinurad Chemical Structure

CAS No. : 1285572-51-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 276 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 Get quote
50 mg USD 1650 Get quote
100 mg USD 2250 Get quote
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Dotinurad is a potent and selective urate reabsorption inhibitor. Dotinurad inhibits urate transporter 1 (URAT1) with an IC50 value of 37.2 nM. Dotinurad acts as a uricosuric agent[1].

IC50 & Target

IC50: 37.2 nM (URAT1)[1]

In Vitro

Dotinurad has higher selectivity for urate transporter 1 (URAT1) versus ATP-binding cassette subfamily G member 2 (ABCG2) and organic anion transporter (OAT) 1/3. Dotinurad weakly inhibits ABCG2, OAT1, and OAT3, with IC50 values of 4.16, 4.08, and 1.32 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dotinurad exhibits low oral bioavailability (2.5 %) and Cmax (415 ng/mL) following oral administration (1.3 mg/kg). Dotinurad also exhibits terminal elimination half-life (T1/2 1.88 h) due to high plasma clearance (24126 mL/h/kg) following oral administration (1.3 mg/kg) in Sprague-Dawley rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

358.20

Formula

C₁₄H₉Cl₂NO₄S

CAS No.

1285572-51-1

SMILES

O=C(C1=CC(Cl)=C(O)C(Cl)=C1)N(C2)C3=CC=CC=C3S2(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 65 mg/mL (181.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7917 mL 13.9587 mL 27.9174 mL
5 mM 0.5583 mL 2.7917 mL 5.5835 mL
10 mM 0.2792 mL 1.3959 mL 2.7917 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DotinuradURAT1Urate transporter 1SLC22A12uratereabsorptiontransporteruricosuricInhibitorinhibitorinhibit

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Dotinurad
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