1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. DS16570511

DS16570511 

Cat. No.: HY-115595 Purity: >98.0%
Handling Instructions

DS16570511 is cell-permeable inhibitor of the mitochondrial calcium uniporter, which blocks the MCU- or MICU1-dependent increase of Ca2+ influx.

For research use only. We do not sell to patients.

DS16570511 Chemical Structure

DS16570511 Chemical Structure

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Description

DS16570511 is cell-permeable inhibitor of the mitochondrial calcium uniporter, which blocks the MCU- or MICU1-dependent increase of Ca2+ influx[1].

IC50 & Target

Mitochondrial calcium uniporter[1]

In Vitro

DS16570511 dose-dependently inhibits serum-induced mitochondrial Ca2+ influx in HEK293A cells with an IC50 of 7 μM[1].
DS16570511 inhibits Ca2+ uptake of isolated mitochondria from human cells, rat heart and pig heart[1].

Molecular Weight

562.44

Formula

C₃₀H₂₅Cl₂N₃O₄

SMILES

O=C(O)CCCN1C=C(C(C2=CC=CC(NCC3=C(C)ON=C3C4=C(Cl)C=CC=C4Cl)=C2)=O)C5=C1C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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DS16570511
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HY-115595
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