Search Result
Results for "
e-z-4-4-dihydroxy-n-desmethyl-tamoxifen-d3
" in MedChemExpress (MCE) Product Catalog:
43
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-133010
-
-
-
- HY-13757AR
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ICI 47699(Standard); (Z)-tamoxifen(Standard); trans-tamoxifen (Standard)
|
Estrogen Receptor/ERR
HSP
Autophagy
Apoptosis
|
Cancer
|
Tamoxifen (Standard) is the analytical standard of Tamoxifen. This product is intended for research and analytical applications. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse .
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-
- HY-13757
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ICI 46474; (Z)-tamoxifen Citrate; trans-tamoxifen Citrate
|
Estrogen Receptor/ERR
HSP
Autophagy
Apoptosis
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Cancer
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Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [3].Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 µM and 1.8 µM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis [4].Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .
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-
-
- HY-13757A
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Tamoxifen
Maximum Cited Publications
83 Publications Verification
ICI 47699; (Z)-tamoxifen; trans-tamoxifen
|
Estrogen Receptor/ERR
HSP
Autophagy
Apoptosis
|
Cancer
|
Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 µM and 1.8 µM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse .
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-
-
- HY-132626S
-
-
-
- HY-13757AS
-
ICI 47699-d5; (Z)-tamoxifen-d5; trans-tamoxifen-d5
|
Estrogen Receptor/ERR
HSP
Autophagy
Apoptosis
|
Cancer
|
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].
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-
- HY-13757AS1
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ICI 47699-d3; (Z)-tamoxifen-d3; trans-tamoxifen-d3
|
Estrogen Receptor/ERR
Apoptosis
Autophagy
HSP
|
Cancer
|
Tamoxifen-d3 is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].
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-
-
- HY-132477S
-
-
-
- HY-131118
-
-
-
- HY-133112
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3-Hydroxy-7-desmethyl agomelatine
|
Melatonin Receptor
5-HT Receptor
|
Neurological Disease
|
7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine . Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist .
|
-
-
- HY-101776A
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desmethyl-SB2343 hydrochloride
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mTOR
PI3K
|
Cancer
|
Desmethyl-VS-5584 hydrochloride
|
-
-
- HY-70002AS
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N-desmethyl MDV 3100-d6
|
|
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N-desmethyl Enzalutamide-d6 is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].
|
-
-
- HY-N9695
-
|
Fungal
|
Infection
|
2,6-Dihydroxy-4-methoxyacetophenone is a phytoalexin, that can be isolated from the root tissue of Sanguisorba minor. 2,6-Dihydroxy-4-methoxyacetophenone exhibits antifungal activity. 2,6-Dihydroxy-4-methoxyacetophenone is a strong germination inhibitor on B. cinerea .
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-
-
- HY-N10692
-
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Others
|
Cancer
|
2-(trans-1,4-Dihydroxy-cyclohexyl)-5,7-dihydroxy-chromone is a flavone derivative that can be found in macrothelypteris torresiana. 2-(trans-1,4-Dihydroxy-cyclohexyl)-5,7-dihydroxy-chromone shows cytotoxic .
|
-
-
- HY-132405S
-
|
COX
Autophagy
|
Others
|
Desmethyl Naproxen-d3 is deuterium labeled Desmethyl Naproxen. Desmethyl Naproxen is the metabolite of anti-inflammatory agent Naproxen[1].
|
-
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- HY-N9736
-
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Calcineurin
|
Infection
Neurological Disease
Inflammation/Immunology
|
6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis .
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- HY-70002A
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N-desmethyl MDV 3100
|
Androgen Receptor
|
Cancer
|
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .
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- HY-N4102
-
|
Fungal
Bacterial
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Infection
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5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities .
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-
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- HY-143930S
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-
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- HY-D0064
-
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Aldose Reductase
|
Metabolic Disease
|
6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation .
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- HY-100064
-
|
|
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O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays .
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- HY-76801
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-
-
- HY-144180S
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-
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- HY-143932S
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-
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- HY-143983S
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-
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- HY-100064S
-
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EGFR
|
Cancer
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O-Desmethyl gefitinib-d8 is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].
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- HY-100064S1
-
|
Isotope-Labeled Compounds
EGFR
|
Cancer
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O-Desmethyl gefitinib-d6 is the deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].
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- HY-134628S
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-
-
- HY-N8577
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-
-
- HY-N8691
-
|
Parasite
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Infection
Inflammation/Immunology
|
2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro .
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- HY-156043
-
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Endogenous Metabolite
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Metabolic Disease
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4,5-Dihydroxy-2,3-pentanedione is a production of S-ribosylhomocysteine. 4,5-Dihydroxy-2,3-pentanedione reacts with boric acid to synthesize AI-2 (an autoinducer) .
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- HY-131085
-
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Drug-Linker Conjugates for ADC
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Cancer
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Desmethyl Vc-seco-DUBA consists a cleavable ADC linker (Desmethyl Vc-seco) and a DNA alkylating agent (DUBA). Desmethyl Vc-seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs) .
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- HY-133113S
-
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5-HT Receptor
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Neurological Disease
|
7-Desmethyl-agomelatine-d3 is a deuterium labeled 7-Desmethyl-agomelatine. 7-Desmethyl-agomelatine is a metabolite of Agomelatine[1].
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- HY-135389S
-
|
Isotope-Labeled Compounds
Drug Metabolite
Antibiotic
|
Infection
|
Desmethyl Levofloxacin-d8 hydrochloride is the deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication .
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-
- HY-W670700
-
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Others
|
Others
|
2,5-Dihydroxy-4-methoxyacetophenone (compounds 3) can be isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa. 2,5-Dihydroxy-4-methoxyacetophenone inhibits glutamate-induced cytotoxicity in hippocampal HT22 cell line .
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-
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- HY-N7181
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Pterosonin E
|
Others
|
Cancer
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7,3'-Dihydroxy-5'-methoxyisoflavone (Pterosonin E) is an arylcoumarin. 7,3'-Dihydroxy-5'-methoxyisoflavone can be used for various biochemical studies .
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- HY-135389S1
-
|
Isotope-Labeled Compounds
Drug Metabolite
Antibiotic
|
Infection
|
Desmethyl Levofloxacin-d8 is deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication[1].
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- HY-12388A
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desmethylclomipramine hydrochloride
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Drug Metabolite
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Neurological Disease
|
N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .
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- HY-135331
-
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Androgen Receptor
Cytochrome P450
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Cancer
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N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .
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- HY-12388AR
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desmethylclomipramine hydrochloride (Standard)
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Drug Metabolite
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Neurological Disease
|
N-Desmethyl Clomipramine (hydrochloride) (Standard) is the analytical standard of N-Desmethyl Clomipramine (hydrochloride). This product is intended for research and analytical applications. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .
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- HY-N8690
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-
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- HY-12771S1
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-
-
- HY-129491
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CGP62221; O-desmethyl PKC412
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PKC
|
Cancer
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O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.
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- HY-132383S
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-
-
- HY-141790S
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-
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- HY-128038S
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-
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- HY-141750S1
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-
-
- HY-143922S
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-
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- HY-118139
-
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COX
|
Inflammation/Immunology
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Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75% .
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-
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- HY-N8796
-
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Others
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Cancer
|
2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a dihydrochalcone compound isolated from Iryanthera juruensis Warb. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a major cytotoxic metabolite when tested against a panel of cancer cell lines .
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- HY-G0010
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-
- HY-118517
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(E)-α-Hydroxy tamoxifen; α-OHTAM
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Drug Metabolite
|
Cancer
|
α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts .
|
-
- HY-131413
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Sanguinine
|
Cholinesterase (ChE)
|
Neurological Disease
|
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM .
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- HY-21297
-
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iGluR
|
Neurological Disease
|
3,5-Dihydroxy-2-naphthoic acid is a Naphthoic acid derivative. Naphthoic acid is a NMDA receptor allosteric modulator .
|
-
- HY-W754151
-
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Isotope-Labeled Compounds
|
Others
|
N-Desmethyl apalutamide-d4 is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .
|
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- HY-13256AS
-
|
Isotope-Labeled Compounds
Drug Metabolite
|
Cancer
|
Desmethyl Erlotinib-d4 is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1][2]. Desmethyl Erlotinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-148677S
-
-
- HY-132709S
-
-
- HY-132344S
-
-
- HY-139519S
-
-
- HY-G0010S
-
-
- HY-144143S
-
-
- HY-N12321
-
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Others
|
Metabolic Disease
|
2',3'-Dihydroxy-4',6'-dimethoxychalcone (compound 1) can inhibit Amyloid β-protein (Aβ42) fibrillization and aggregation. 2',3'-Dihydroxy-4',6'-dimethoxychalcone has oral activity and can be detected in the brain .
|
-
- HY-12771
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Mebeverine metabolite O-desmethyl Mebeverine acid
|
Drug Metabolite
|
Neurological Disease
|
O-desmethyl Mebeverine acid is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
|
-
- HY-N9732
-
|
Others
|
Others
|
3,4-Dihydroxy-2-methoxyxanthone is a natural product, that can be isolated from the roots of Hypericum oblongifolium .
|
-
- HY-108416
-
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Others
|
Others
|
5,7-Dihydroxy-4-methylphthalide is a key intermediate in the synthesis of Mycophenolic acid and a secondary metabolite of Aspergillus flavus .
|
-
- HY-12388AS
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desmethylclomipramine D3 hydrochloride
|
Drug Metabolite
|
Neurological Disease
|
N-Desmethyl Clomipramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]
|
-
- HY-135387
-
|
Drug Metabolite
|
Neurological Disease
|
4-Desmethyl Istradefylline is a metabolite of Istradefylline. 4-Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease .
|
-
- HY-12771S2
-
-
- HY-12771S
-
-
- HY-100652A
-
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Factor Xa
|
Cardiovascular Disease
|
O-Desmethyl apixaban sulfate sodium is a major circulating metabolite of Apixaban in humans. O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a Ki of 58 μM .
|
-
- HY-N9311
-
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Others
|
Others
|
2,3-Dihydroxy-4-methoxybenzoic acid is a compound isolated from extracted from sweet cherry fruits (Prunus avium) .
|
-
- HY-N9269
-
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Others
|
Others
|
1,7-Dihydroxy-2,3-dimethoxyxanthone is a xanthone that can be found in Polygala cyparissias .
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-
- HY-144144S
-
-
- HY-128038
-
|
Opioid Receptor
|
Neurological Disease
|
N-Desmethyl-loperamide is a major metabolite of loperamide, a drug that selectively activates peripheral μopioid receptors with a Ki value of 0.16 nM. N-Desmethyl-loperamide is a substrate of the ATP-dependent efflux transporter P-glycoprotein .
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- HY-143767S
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-
- HY-135847
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SSR97213
|
Parasite
Drug Metabolite
|
Infection
|
Desmethyl ferroquine (SSR97213) is the active and major metabolite of Ferroquine. Ferroquine is an antimalarial. Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains .
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- HY-N1665
-
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Others
|
Cancer
|
2',4'-Dihydroxy-3',6'-dimethoxychalcone is a natural product that can be isolated from Polygonum Lapathifolium. 2',4'-Dihydroxy-3',6'-dimethoxychalcone inhibits the growth of CCRF-CEM leukaemia cells and CEM/ADR5000 cells, with IC50 values of 10.67 and 18.60 μM, respectively .
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-
- HY-103567
-
|
mGluR
|
Neurological Disease
|
Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice .
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-
- HY-N11999
-
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Others
|
Others
|
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) can be isolated from Dendrobium infundibulum (D. infundibulum). 5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl has no inhibitory activity against α-glucosidase and pancreatic lipase .
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-
- HY-N3291
-
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Others
|
Others
|
Methyl-3-(2,4-dihydroxy phenyl) propanoate is a phenylpropanoic ester with antifeedant activity .
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-
- HY-76915
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-
- HY-N1667
-
|
Parasite
|
Infection
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2',4'-Dihydroxy-6'-Methoxyacetophenone is a phenolic acetophenone from Artemisia annua. Artemisia annua is an analog of Artemisinin that is effective in the research of malaria .
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-
- HY-N10853
-
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Others
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Cancer
|
3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone is a nature product that could be isolated from the fruits of Vitex rotundifolia. 3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone has potent cytotoxic activity against A549 and HepG-2 cell lines .
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- HY-Z3203S
-
-
- HY-133925S1
-
-
- HY-133926S
-
-
- HY-143931S
-
-
- HY-143949S
-
-
- HY-143810S
-
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Isotope-Labeled Compounds
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Others
|
N-Desmethyl Mifepristone-d3 is the deuterium labeled N-Desmethyl Mifepristone[1]. N-Desmethyl Mifepristone-d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-N2738
-
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Others
|
Others
|
(2S)-7,4'-Dihydroxy-3'-prenylflavan is a natural product .
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-
- HY-150544S
-
|
Isotope-Labeled Compounds
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Others
|
N-Desmethyl Selegiline-dd5 hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride[1]. N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-129491S
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CGP62221-d5; O-desmethyl PKC412-d5
|
Isotope-Labeled Compounds
Drug Metabolite
|
Cancer
|
O-Desmethyl Midostaurin-d5 is a deuterium labeled O-Desmethyl PKC412. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism[1].
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-
- HY-N4291
-
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Others
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Neurological Disease
|
1,7-Dihydroxy-2,3-methylenedioxyxanthone is found in Polygala cyparissias which is a small herb found in Brazil, Argentina and Uruguay.
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-
- HY-N8184
-
-
- HY-N12371
-
|
Others
|
Others
|
5,8-Dihydroxy-6,7-dimethoxyflavone, isolated from aerial parts of Gnaphalium gaudichaudianum, has antitumor activity .
|
-
- HY-131254
-
|
Drug Metabolite
|
Neurological Disease
|
(S)-O-Desmethyl Venlafaxine N-Oxide is a N-oxyde of (S)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine . Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class .
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- HY-133925S
-
-
- HY-N7509
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Gallacetophenone-4-methyl ether
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Others
|
Neurological Disease
|
2,3-Dihydroxy-4-methoxyacetophenone is a neuroprotective compound from Cynenchum paniculatum. 2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may has the potential for the treatment of Alzheimer's disease research .
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-
- HY-141453
-
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RIP kinase
|
Cancer
|
Desmethyl-WEHI-345 analog is a protein kinase inhibitor extracted from patent WO2012003544A1, example 12. Desmethyl-WEHI-345 analog can be used for the research of colon cancer .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D0064
-
|
Dyes
|
6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-13757AS
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Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].
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- HY-132477S
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(Z)-4-Hydroxy Tamoxifen-d5 is the deuterium labeled (Z)-4-Hydroxy Tamoxifen[1].
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- HY-132405S
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Desmethyl Naproxen-d3 is deuterium labeled Desmethyl Naproxen. Desmethyl Naproxen is the metabolite of anti-inflammatory agent Naproxen[1].
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- HY-132626S
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N-Desmethyl Tamoxifen-d5 is the deuterium labeled N-Desmethyl Tamoxifen[1].
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- HY-13757AS1
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Tamoxifen-d3 is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].
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- HY-143930S
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Dihydroxy Bendamustine-d8 is the deuterium labeled Dihydroxy Bendamustine[1].
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- HY-144180S
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Fluometuron-desmethyl-d3 is the deuterium labeled Fluometuron-desmethyl[1].
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- HY-143932S
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Desmethyl Bendamustine-d8 (hydrochloride) is the deuterium labeled Desmethyl Bendamustine hydrochloride[1].
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- HY-143983S
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Desmethyl Mirtazapine-d4 hydrochloride is the deuterium labeled Desmethyl Mirtazapine hydrochloride[1].
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- HY-100064S
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O-Desmethyl gefitinib-d8 is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].
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- HY-100064S1
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O-Desmethyl gefitinib-d6 is the deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].
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- HY-134628S
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(Rac)-8,14-Dihydroxy Efavirenz-d4 is the deuterium labeled (Rac)-8,14-Dihydroxy Efavirenz[1].
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- HY-133113S
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7-Desmethyl-agomelatine-d3 is a deuterium labeled 7-Desmethyl-agomelatine. 7-Desmethyl-agomelatine is a metabolite of Agomelatine[1].
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- HY-135389S
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Desmethyl Levofloxacin-d8 hydrochloride is the deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication .
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- HY-135389S1
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Desmethyl Levofloxacin-d8 is deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication[1].
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- HY-12771S1
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O-desmethyl Mebeverine acid-d5 (hydrochloride) is the deuterium labeled O-desmethyl Mebeverine acid.
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- HY-132383S
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24,25-Dihydroxy Vitamin D2-d3 is the deuterium labeled 24,25-Dihydroxy Vitamin D2[1].
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- HY-141790S
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O-Desmethyl Indomethacin-d4 is the deuterium labeled O-Desmethyl Indomethacin[1].
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- HY-128038S
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N-Desmethyl-loperamide-d3 is the deuterium labeled N-Desmethyl-loperamide[1].
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- HY-141750S1
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N-Desmethyl Zolmitriptan-d3 is the deuterium labeled N-Desmethyl Zolmitriptan[1].
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- HY-143922S
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N-Desmethyl Bedaquiline-d6 is the deuterium labeled N-Desmethyl Bedaquiline[1].
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- HY-W754151
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N-Desmethyl apalutamide-d4 is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .
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- HY-13256AS
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Desmethyl Erlotinib-d4 is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1][2]. Desmethyl Erlotinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-148677S
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2,3-Dihydroxy-2-methylbutanoic acid-d3 is the deuterium labeled 2,3-Dihydroxy-2-methylbutanoic acid[1].
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- HY-132709S
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N-Desmethyl-diltiazem-d4 (hydrochloride) is the deuterium labeled N-Desmethyl-diltiazem hydrochloride[1].
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- HY-132344S
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N-Desmethyl asenapine-d4 (hydrochloride) is the deuterium labeled N-Desmethyl asenapine hydrochloride[1].
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- HY-139519S
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N-Desmethyl diphenhydramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl diphenhydramine hydrochloride[1].
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- HY-G0010S
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N-desmethyl Netupitant-d6 is the deuterium labeled N-desmethyl Netupitant, which is a metabolite of Netupitant.
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- HY-144143S
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N-Desmethyl Olopatadine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Olopatadine hydrochloride[1].
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- HY-12388AS
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N-Desmethyl Clomipramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]
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- HY-12771S2
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O-Desmethyl Mebeverine acid-d6 is deuterium labeled O-desmethyl Mebeverine acid.
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- HY-12771S
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O-Desmethyl Mebeverine acid-d5 is the deuterium labeled O-desmethyl Mebeverine acid.
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- HY-144144S
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(E)-N-Desmethyl Olopatadine-d3 (hydrochloride) is the deuterium labeled (E)-N-Desmethyl Olopatadine.
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- HY-143767S
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N-Desmethyl Azelastine-d4-1 is the deuterium labeled N-Desmethyl Azelastine[1].
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- HY-Z3203S
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N-Desmethyl Rosuvastatin-d6 (disodium) is the deuterium labeled N-Desmethyl Rosuvastatin disodium[1].
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- HY-133925S1
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6-O-Desmethyl donepezil-d5 (hydrochloride) is deuterium labeled 6-O-Desmethyl donepezil.
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- HY-133926S
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5-O-Desmethyl donepezil-d5 is deuterium labeled 5-O-Desmethyl donepezil.
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- HY-143931S
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N-Desmethyl citalopram-d4 (oxalate) is the deuterium labeled N-Desmethyl citalopram oxalate[1].
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- HY-143949S
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(Rac)-N-desmethyl Dapoxetine-d7 hydrochloride is the deuterium labeled (Rac)-N-desmethyl Dapoxetine hydrochloride[1].
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- HY-143810S
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N-Desmethyl Mifepristone-d3 is the deuterium labeled N-Desmethyl Mifepristone[1]. N-Desmethyl Mifepristone-d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-150544S
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N-Desmethyl Selegiline-dd5 hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride[1]. N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-129491S
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O-Desmethyl Midostaurin-d5 is a deuterium labeled O-Desmethyl PKC412. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism[1].
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- HY-133925S
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6-O-Desmethyl donepezil-d5 is the deuterium labeled 6-O-Desmethyl donepezil[1].
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Cat. No. |
Product Name |
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Classification |
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- HY-13256AS
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Alkynes
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Desmethyl Erlotinib-d4 is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1][2]. Desmethyl Erlotinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-150544S
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Alkynes
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N-Desmethyl Selegiline-dd5 hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride[1]. N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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