1. Metabolic Enzyme/Protease
  2. Epoxide Hydrolase
  3. EC5026

EC5026 (Synonyms: BPN-19186)

Cat. No.: HY-135653 Purity: 98.01% ee.: 96.10%
Handling Instructions

EC5026 (BPN-19186) is a first-in-class, non-opioid and orally active soluble Epoxide Hydrolase (sEH) inhibitor. EC5026 shows efficacy for inflammatory and neuropathic pain.

For research use only. We do not sell to patients.

EC5026 Chemical Structure

EC5026 Chemical Structure

CAS No. : 1809885-32-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 312 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

EC5026 (BPN-19186) is a first-in-class, non-opioid and orally active soluble Epoxide Hydrolase (sEH) inhibitor. EC5026 shows efficacy for inflammatory and neuropathic pain[1].

In Vivo

EC5026 (BPN-19186) has already shown efficacy for treating pain with no apparent adverse or addictive effects in laboratory animals and relieving naturally occurring pain in dogs, cats and horses[1].

Clinical Trial
Molecular Weight

405.39

Formula

C₁₈H₂₃F₄N₃O₃

CAS No.

1809885-32-2

SMILES

O=C(NC1CCN(C([[email protected]@H](C)CC)=O)CC1)NC2=CC=C(OC(F)(F)F)C(F)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (616.69 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4668 mL 12.3338 mL 24.6676 mL
5 mM 0.4934 mL 2.4668 mL 4.9335 mL
10 mM 0.2467 mL 1.2334 mL 2.4668 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.13 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.13 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.13 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.01% ee.: 96.10%

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× = ×
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Keywords:

EC5026BPN-19186EC 5026EC-5026BPN19186BPN 19186Epoxide HydrolaseSolubleEpoxideHydrolasesEHanalgesicanti-inflammatorymediatorspainInhibitorinhibitorinhibit

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EC5026
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HY-135653
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