1. Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
    Apoptosis
  2. Reactive Oxygen Species
    Apoptosis
  3. Elesclomol

Elesclomol (Synonyms: STA-4783)

Cat. No.: HY-12040 Purity: 99.03%
Handling Instructions

Elesclomol (STA-4783) is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol shows antitumor activity against a broad range of cancer cell types. Elesclomol is also a highly lipophilic Cu2+-binding molecule. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research.

For research use only. We do not sell to patients.

Elesclomol Chemical Structure

Elesclomol Chemical Structure

CAS No. : 488832-69-5

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Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
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10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
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5 mg USD 120 In-stock
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10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
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100 mg USD 1140 In-stock
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Customer Review

Based on 7 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Elesclomol purchased from MCE. Usage Cited in: Biomolecules. 2019 Jul 24;9(8):298. 

    Confocal images of MitoSOX fluorescence intensity in CV-1 cells at the 20-min time point after E:C (elesclomol:copper)- treatment in the presence and absence of the mitochondrial superoxide scavenger MitoTEMPO.
    • Biological Activity

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    • Customer Review

    Description

    Elesclomol (STA-4783) is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol shows antitumor activity against a broad range of cancer cell types. Elesclomol is also a highly lipophilic Cu2+-binding molecule. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research[1][2].

    In Vitro

    Elesclomol (200 nM; 18 hours) treatment increases the number of early and late apoptotic cells in HSB2 cells. Elesclomol induces apoptosis in cancer cells through the induction of oxidative stress[1].
    Elesclomol significantly inhibits the cell viability of SK-MEL-5, MCF-7, and HL-60 cells with IC50 values of 110 nM, 24 nM and 9 nM, respectively[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Apoptosis Analysis[1]

    Cell Line: HSB2 cells
    Concentration: 200 nM
    Incubation Time: 18 hours
    Result: Increased the number of early and late apoptotic cells.
    In Vivo

    Elesclomol (10 mg/kg; subcutaneous injection; every three days from post-natal day 5 to 26 and once weekly until post-natal day 54) treatment ameliorates severe cardiac pathology with a partial reduction in hypertrophy. Cardiac [Cu] increased with Elesclomol treatment from a vehicle knockout level of 34 to 55%[2].
    Elesclomol escorted copper to the mitochondria and increased cytochrome c oxidase levels in the brain. Elesclomol prevents detrimental neurodegenerative changes and improved the survival of the mottled-brindled mouse[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Cardiac Ctr1 knockout mice[2]
    Dosage: 10 mg/kg
    Administration: Subcutaneous injection; every three days from post-natal day 5 to 26 and once weekly until post-natal day 54
    Result: Ameliorated severe cardiac pathology with a partial reduction in hypertrophy.
    Clinical Trial
    Molecular Weight

    400.52

    Formula

    C₁₉H₂₀N₄O₂S₂

    CAS No.
    SMILES

    S=C(C1=CC=CC=C1)N(NC(CC(NN(C(C2=CC=CC=C2)=S)C)=O)=O)C

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 22 mg/mL (54.93 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4968 mL 12.4838 mL 24.9675 mL
    5 mM 0.4994 mL 2.4968 mL 4.9935 mL
    10 mM 0.2497 mL 1.2484 mL 2.4968 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.80%

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    Keywords:

    ElesclomolSTA-4783STA4783STA 4783Reactive Oxygen SpeciesApoptosisproapoptoticoxidativestressanticancerHsp70coppermitochondriaInhibitorinhibitorinhibit

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