1. Anti-infection
    Autophagy
  2. Parasite
    Autophagy
  3. Emetine dihydrochloride

Emetine dihydrochloride 

Cat. No.: HY-B1479A Purity: >99.0%
Handling Instructions

Emetine (dihydrochloride) is an anti-protozoal drug previously used for intestinal and tissue amoebiasis.

For research use only. We do not sell to patients.

Emetine dihydrochloride Chemical Structure

Emetine dihydrochloride Chemical Structure

CAS No. : 316-42-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 108 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Emetine dihydrochloride:

Top Publications Citing Use of Products

Publications Citing Use of MCE Emetine dihydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Emetine (dihydrochloride) is an anti-protozoal drug previously used for intestinal and tissue amoebiasis[1].

In Vitro

Emetine dihydrochloride is reported to have an IC50 value of 1 nM on the drug sensitive 3D7 P. falciparum parasite strains. Dose response curves are determined for both drugs using K1 resistant isolates and IC50 values of 47 nM and 2.6 nM established for emetine dihydrochloride hydrate and DHA, respectively[1].
After the lymphoblasts are treated with emetine dihydrochloride, the expression level of the mutant allele is elevated almost equally to the wild-type alleles by direct sequencing of the corresponding cDNA[2].
Emetine dihydrochloride is identified as a lead compound with significant concentration dependent suppression of PEDF-induced TNF secretion and an IC50 of 146 nM. Emetine dihydrochloride inhibits PEDF-mediated TNF release without affecting cell viability and binds to PEDF receptor ATGL with high-binding affinity (KD=14.3 nM)[3].
Emetine dihydrochloride reduces cell viability, induces apoptosis, promptes AML cells towards differentiation and downregulates HIF-1α[4].

In Vivo

Emetine dihydrochloride (0.002, 0.02, 0.2 and 2 mg/kg) not only attenuates blood glucose levels in dose-dependent way but also induces a persistent attenuation of blood glucose levels. Daily administration of emetine dihydrochloride dose-dependently attenuates hyperglycemic response by d 21. Consistent with this observation, administration of emetine dihydrochloride, but not the vehicle control, results in a sustained attenuation of blood glucose levels. Emetine dihydrochloride improves disease severity in a spontaneous model of NOD T1D[3].
Emetine dihydrochloride (1 mg/kg) reduces both leukemia burden in an in vivo xenotransplantation mouse model and the clonogenic capacity of leukemic cells upon treatment[4].

Molecular Weight

553.56

Formula

C₂₉H₄₂Cl₂N₂O₄

CAS No.

316-42-7

SMILES

CC[[email protected]@H]1[[email protected]](C[[email protected]@]2([H])C3=CC(OC)=C(OC)C=C3CCN2C1)C[[email protected]]4([H])C5=CC(OC)=C(OC)C=C5CCN4.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (90.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8065 mL 9.0324 mL 18.0649 mL
5 mM 0.3613 mL 1.8065 mL 3.6130 mL
10 mM 0.1806 mL 0.9032 mL 1.8065 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

EmetineParasiteAutophagyanti-protozoalintestinaltissueamoebiasisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Emetine dihydrochloride
Cat. No.:
HY-B1479A
Quantity:
MCE Japan Authorized Agent: