1. Anti-infection
    Cell Cycle/DNA Damage
    Autophagy
  2. Parasite
    DNA/RNA Synthesis
    Autophagy
    Bacterial
    Antibiotic
  3. Emetine

Emetine 

Cat. No.: HY-B1479
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Emetine, derived from the ipecac root, is a potent anti-protozoal and emetic agent. Emetine inhibits viral polymerases and inhibits Zika and Ebola virus infections. Emetine potently inhibits autophagy and has anti-malarial, anti-bacterial and anti-amoebic effect.

For research use only. We do not sell to patients.

Emetine Chemical Structure

Emetine Chemical Structure

CAS No. : 483-18-1

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Description

Emetine, derived from the ipecac root, is a potent anti-protozoal and emetic agent. Emetine inhibits viral polymerases and inhibits Zika and Ebola virus infections. Emetine potently inhibits autophagy and has anti-malarial, anti-bacterial and anti-amoebic effect[1][2][3][4].

In Vitro

Emetine accumulates SQSTM1 and MAP1LC3B in SNB-19 cells, indicating autophagy is blocked[1].
Emetine dose-dependently decreases NS1 protein level in HEK293 cells infected with the African prototype, ZIKV MR766 (IC50=52.9 nM). Emetine directly inhibits ZIKV NS5 RNA polymerase activity with an IC50 of 121 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay[1]

Cell Line: SNB-19 cells
Concentration: 25, 50, 100, 200 nM
Incubation Time: For 24 hours
Result: Showed the accumulation of SQSTM1 and MAP1LC3B, indicating autophagy was blocked.
In Vivo

Emetine (1, 2 mg/kg/day; IP; for 3 days) significantly reduces the serum viral load of ZIKV infected Ifnar1−/− mice[1].
Emetine (1 mg/kg/day; retro-orbital injection; for six days) reduces the levels of circulating ZIKV approximately 10-fold in three-month-old female SJL mice with ZIKVBR[1].
Emetine (0.002, 0.02, 0.2, 2 mg/kg/day; i.p.) not only attenuates blood glucose levels in dose-dependent way but also induces a persistent attenuation of blood glucose levels in C57Bl/6 male mice (20-25 g) [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ifnar1−/− mice[1]
Dosage: 1, 2 mg/kg
Administration: IP; once daily for 3 days
Result: Significantly reduced the serum viral load of ZIKV infected Ifnar1−/− mice.
Molecular Weight

480.64

Formula

C₂₉H₄₀N₂O₄

CAS No.

483-18-1

SMILES

CC[[email protected]@H]1[[email protected]](C[[email protected]@]2([H])C3=CC(OC)=C(OC)C=C3CCN2C1)C[[email protected]]4([H])C5=CC(OC)=C(OC)C=C5CCN4

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

EmetineParasiteDNA/RNA SynthesisAutophagyBacterialAntibioticipecacrootanti-protozoalemeticviralpolymerasesZikaEbolaanti-malarialInhibitorinhibitorinhibit

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