2. Membrane Transporter/Ion Channel
  3. SGLT
  4. Empagliflozin

Empagliflozin  (Synonyms: BI 10773)

Cat. No.: HY-15409 Purity: 99.90%
COA Handling Instructions

Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2.

For research use only. We do not sell to patients.

Empagliflozin Chemical Structure

Empagliflozin Chemical Structure

CAS No. : 864070-44-0

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
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10 mM * 1 mL
ready for reconstitution
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10 mg USD 70 In-stock
50 mg USD 90 In-stock
100 mg USD 120 In-stock
200 mg USD 180 In-stock
500 mg USD 250 In-stock
1 g USD 450 In-stock
5 g USD 1250 In-stock
10 g USD 1950 In-stock
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Customer Review

Based on 49 publication(s) in Google Scholar

Empagliflozin Related Antibodies

Top Publications Citing Use of Products

47 Publications Citing Use of MCE Empagliflozin

Proliferation Assay
WB

    Empagliflozin purchased from MCE. Usage Cited in: Biochem Pharmacol. 2018 Jun;152:45-59.  [Abstract]

    Effects of BMS-512148 and Empagliflozin on p62 expression in LPS-untreated and LPS-treated RAW264.7 cells.

    Empagliflozin purchased from MCE. Usage Cited in: JACC Basic Transl Sci. 2017 Aug;2(3):347-354.

    Improved In Vivo Cardiac Function in Empagliflozin-Treated Mice With Heart Failure Is PreservedEx Vivo. Hearts from vehicle- and Empa-treated mice with HF are perfused ex vivo to measure cardiac function. Cardiac output (A) and cardiac work (B) are measured using ex vivo perfused working hearts.

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2[1].

    IC50 & Target

    IC50: 3.1 nM (SGLT-2), 1.1 μM (SGLT-5), 2 μM (SGLT-6), 8.3 μM (SGLT-1), 11 μM (SGLT-4)[1]
    In Vitro

    Empagliflozin is a potent and competitive SGLT-2 inhibitor with an excellent selectivity profile and the highest selectivity window of the tested SGLT-2 inhibitors over hSGLT-1. Empagliflozin inhibits the uptake of [14C]-alpha-methyl glucopyranoside (AMG) via hSGLT-2 in a dose-dependent manner with an IC50 of 3.1 nM, but is less potent for other SGLTs (IC50 range: 1100-11000 nM). [3H]-Empagliflozin displays a high affinity for SGLT-2 with a mean Kd of 57±37 nM in the absence of glucose in kinetic binding experiments[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Empagliflozin Related Antibodies
    In Vivo

    Glucose intolerance is significantly improved after 8 days of Empagliflozin treatment at either dose (3mg/kg Empagliflozin 3058±180 vs 10mg/kg Empagliflozin 3090±219). Therefore, acute treatment with Empagliflozin has a beneficial effect on hyperglycemia and glucose intolerance. Since there are no significant differences in blood glucose homeostasis with the two different doses of Empagliflozin, and random blood glucose levels of T1DM mice are significantly improved by 3mg/kg of Empagliflozin, the effect of the lower dose of Empagliflozin (3mg/kg) is investigated on preserving β-cell mass and function[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    450.91

    Appearance

    Solid

    Formula

    C23H27ClO7
    CAS No.
    SMILES

    ClC(C=CC([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)=C2)=C2CC(C=C3)=CC=C3O[C@H]4CCOC4
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (110.89 mM; Need ultrasonic)

    H2O : 0.11 mg/mL (0.24 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2177 mL 11.0887 mL 22.1774 mL
    5 mM 0.4435 mL 2.2177 mL 4.4355 mL
    10 mM 0.2218 mL 1.1089 mL 2.2177 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  0.5%HPMC

      Solubility: 5 mg/mL (11.09 mM); Suspension solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% saline

      Solubility: ≥ 2.87 mg/mL (6.36 mM); Clear solution

    • 3.

      Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.87 mg/mL (6.36 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (4.61 mM); Clear solution

    • 5.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (4.61 mM); Clear solution

    • 6.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (4.61 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.90%

    COA (249 KB) LCMS (132 KB) Elemental Analysis Report (106 KB)

    Handling Instructions (2659 KB)
    References
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    Empagliflozin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Empagliflozin864070-44-0BI 10773BI10773BI-10773SGLTSodium-dependent glucose cotransportersInhibitorinhibitorinhibit

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