1. Metabolic Enzyme/Protease
  2. Renin
  3. Enalkiren

Enalkiren (A-64662) is a potent dipeptide renin inhibitor with an IC50 of 0.78 nM in a purified renal renin-angiotensinogen system (pH=6.0). Enalkiren suppresses renin activity, and also reduces systolic and diastolic blood pressure. Enalkiren can be used to research essential hypertension.

For research use only. We do not sell to patients.

Enalkiren Chemical Structure

Enalkiren Chemical Structure

CAS No. : 113082-98-7

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Description

Enalkiren (A-64662) is a potent dipeptide renin inhibitor with an IC50 of 0.78 nM in a purified renal renin-angiotensinogen system (pH=6.0). Enalkiren suppresses renin activity, and also reduces systolic and diastolic blood pressure. Enalkiren can be used to research essential hypertension[1][2].

IC50 & Target

IC50: 23 nM (hamster dipeptide renin), 14 nM (human dipeptide renin), 2.3 nM (cynomolgus monkey dipeptide renin)[2]

In Vitro

Enalkiren inhibits the endogenous renin-angiotensinogen reaction with an IC50 value of 23 nM, 14 nM and 2.3 nM in hamster, human and cynomolgus monkey plasma, respectively, at pH 7.4[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Enalkiren (0.01-10 mg/kg; i.v.; single dosage) reduces mean arterial blood pressure in cynomolgus monkey[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkey[2]
Dosage: 0.01-10 mg/kg
Administration: i.v.; single dosage
Result: Reduced mean arterial blood pressure in a dose-related manner.
Molecular Weight

656.86

Formula

C35H56N6O6

CAS No.
SMILES

O=C(N[C@H]([C@@H](O)[C@@H](O)CC(C)C)CC1CCCCC1)[C@@H](NC([C@@H](NC(CC(C)(N)C)=O)CC(C=C2)=CC=C2OC)=O)CC3=CN=CN3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Enalkiren Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Enalkiren
Cat. No.:
HY-105276
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