1. Protein Tyrosine Kinase/RTK
  2. Anaplastic lymphoma kinase (ALK)
  3. Envonalkib

Envonalkib  (Synonyms: TQ-B3139; CT-71)

Cat. No.: HY-145566 Purity: 99.73%
COA Handling Instructions

Envonalkib is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib can be used for the research of non-small cell lung cancer.

For research use only. We do not sell to patients.

Envonalkib Chemical Structure

Envonalkib Chemical Structure

CAS No. : 1621519-26-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 528 In-stock
Solution
10 mM * 1 mL in DMSO USD 528 In-stock
Solid
5 mg USD 480 In-stock
10 mg USD 800 In-stock
25 mg USD 1550 In-stock
50 mg USD 2400 In-stock
100 mg USD 3600 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Envonalkib:

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  • Biological Activity

  • Purity & Documentation

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Description

Envonalkib is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib can be used for the research of non-small cell lung cancer[1].

IC50 & Target

IC50: 1.96 nM (WT-ALK), 35.1 nM (mutated L1196M-ALK), 61.3 nM (mutated G1269S-ALK)[1]

In Vivo

Envonalkib (formula I) (12.5-25 mg/kg; p.o. once daily for 14 days) inhibits the growth of human non-small cell lung cancer NCI-H2228 nude mice xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

506.40

Formula

C24H26Cl2FN5O2

CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

COC1=CC(N2[C@H](CNCC2)C)=NC=C1C3=CN=C(N)C(O[C@@H](C4=C(C(F)=CC=C4Cl)Cl)C)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (197.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9747 mL 9.8736 mL 19.7472 mL
5 mM 0.3949 mL 1.9747 mL 3.9494 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9747 mL 9.8736 mL 19.7472 mL 49.3681 mL
5 mM 0.3949 mL 1.9747 mL 3.9494 mL 9.8736 mL
10 mM 0.1975 mL 0.9874 mL 1.9747 mL 4.9368 mL
15 mM 0.1316 mL 0.6582 mL 1.3165 mL 3.2912 mL
20 mM 0.0987 mL 0.4937 mL 0.9874 mL 2.4684 mL
25 mM 0.0790 mL 0.3949 mL 0.7899 mL 1.9747 mL
30 mM 0.0658 mL 0.3291 mL 0.6582 mL 1.6456 mL
40 mM 0.0494 mL 0.2468 mL 0.4937 mL 1.2342 mL
50 mM 0.0395 mL 0.1975 mL 0.3949 mL 0.9874 mL
60 mM 0.0329 mL 0.1646 mL 0.3291 mL 0.8228 mL
80 mM 0.0247 mL 0.1234 mL 0.2468 mL 0.6171 mL
100 mM 0.0197 mL 0.0987 mL 0.1975 mL 0.4937 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Envonalkib
Cat. No.:
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