1. Membrane Transporter/Ion Channel
  2. P-glycoprotein
  3. Epoxylathyrol

Epoxylathyrol, an epoxylathyrane derivative isolated from the Euphorbia boetica, is a P-glycoprotein (P-gp) inhibitor. Epoxylathyrol is a P-gp-mediated multidrug resistance (MDR) reverser.

For research use only. We do not sell to patients.

Epoxylathyrol Chemical Structure

Epoxylathyrol Chemical Structure

CAS No. : 28649-60-7

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Description

Epoxylathyrol, an epoxylathyrane derivative isolated from the Euphorbia boetica, is a P-glycoprotein (P-gp) inhibitor. Epoxylathyrol is a P-gp-mediated multidrug resistance (MDR) reverser[1][2].

In Vitro

Epoxylathyrol has no significant antiproliferative activity in EPG85-257P (parental; IC50>100 uM), EPG85-257RNOV (multidrug resistance [MDR] phenotype; IC50>100 uM), and EPG85-257RDB (multidrug resistance [MDR] phenotype; IC50=70.53 uM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

350.45

Formula

C20H30O5

CAS No.
SMILES

O[C@@H]1[C@]2(CO2)CC[C@@]3([H])[C@](/C=C(C([C@@]4([C@]1([H])[C@H]([C@H](C4)C)O)O)=O)\C)([H])C3(C)C

Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Epoxylathyrol Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Epoxylathyrol
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HY-N0425
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