1. Anti-infection Immunology/Inflammation
  2. EBV Toll-like Receptor (TLR)
  3. Eritoran

Eritoran (E5564 free base) is a Toll-like receptor 4 (TLR4) antagonist. Eritoran protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran inhibits pathogenesis of filovirus infection. Eritoran has anti-inflammatory activity.

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Eritoran Chemical Structure

Eritoran Chemical Structure

CAS No. : 185955-34-4

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Description

Eritoran (E5564 free base) is a Toll-like receptor 4 (TLR4) antagonist. Eritoran protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran inhibits pathogenesis of filovirus infection. Eritoran has anti-inflammatory activity[1][2].

IC50 & Target[1]

TLR4

 

In Vivo

Eritoran (233 μg/mouse; i.p.; 10 days) protects mouse from EBOV lethal infection, results 70% survived until the end of the study[1].
Eritoran (2 μL of 1.1 mg/mL, corneal infusion) inhibits LPS (HY-D1056) -induced corneal inflammation in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice challenged with lethal EBOV[1]
Dosage: 233 μg/mouse
Administration: Intraperitoneal injection; 10 days
Result: Reduced granulocytosis and results in a higher percentage of activated CD11b+ Ly6G/Ly6C+ neutrophils.
Dramatically reduced the levels of IFN-γ-secreting CD8+ and CD4+ T cells and IL-17A-secreting CD4+ T cells.
Clinical Trial
Molecular Weight

1313.66

Formula

C66H126N2O19P2

CAS No.
SMILES

CCCCCCC[C@@H](OC)CCO[C@@H]1[C@H]([C@@H](O[C@H](COC)[C@H]1OP(O)(O)=O)OC[C@@H]2[C@H]([C@@H]([C@@H](NC(CC(CCCCCCCCCCC)=O)=O)[C@@H](OP(O)(O)=O)O2)OCCCCCCCCCC)O)NC(CCCCCCCCC/C=C\CCCCCC)=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Eritoran
Cat. No.:
HY-105070
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