1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. Ervogastat

Ervogastat (Synonyms: PF-06865571)

Cat. No.: HY-111620
Handling Instructions

Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor (DGAT2i). Ervogastat alone reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH). Ervogastat combination with Clesacostat (an acetyl CoA-carboxylase inhibitor (ACCi)) can be used for the research of NASH with liver fibrosis therapy.

For research use only. We do not sell to patients.

Ervogastat Chemical Structure

Ervogastat Chemical Structure

CAS No. : 2186700-33-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor (DGAT2i). Ervogastat alone reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH)[1]. Ervogastat combination with Clesacostat (an acetyl CoA-carboxylase inhibitor (ACCi)) can be used for the research of NASH with liver fibrosis therapy[1][2].

IC50 & Target

IC50: DGAT2[1]

Clinical Trial
Molecular Weight

407.42

Formula

C₂₁H₂₁N₅O₄

CAS No.

2186700-33-2

SMILES

CCOC1=CC=CN=C1OC2=CN=CC(C3=NC=C(C(N[[email protected]@H]4COCC4)=O)C=N3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (306.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4545 mL 12.2723 mL 24.5447 mL
5 mM 0.4909 mL 2.4545 mL 4.9089 mL
10 mM 0.2454 mL 1.2272 mL 2.4545 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.11 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ErvogastatPF-06865571PF06865571PF 06865571AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferasesteatosishepatic triglyceride NASHNAFLDliver fibrosismonotherapyInhibitorinhibitorinhibit

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Ervogastat
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