1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. Ervogastat

Ervogastat (Synonyms: PF-06865571)

Cat. No.: HY-111620
Handling Instructions

Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor (DGAT2i). Ervogastat alone reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH). Ervogastat combination with Clesacostat (an acetyl CoA-carboxylase inhibitor (ACCi)) can be used for the research of NASH with liver fibrosis therapy.

For research use only. We do not sell to patients.

Ervogastat Chemical Structure

Ervogastat Chemical Structure

CAS No. : 2186700-33-2

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Description

Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor (DGAT2i). Ervogastat alone reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH)[1]. Ervogastat combination with Clesacostat (an acetyl CoA-carboxylase inhibitor (ACCi)) can be used for the research of NASH with liver fibrosis therapy[1][2].

IC50 & Target

IC50: DGAT2[1]

Molecular Weight

407.42

Formula

C₂₁H₂₁N₅O₄

CAS No.

2186700-33-2

SMILES

CCOC1=CC=CN=C1OC2=CN=CC(C3=NC=C(C(N[[email protected]@H]4COCC4)=O)C=N3)=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ErvogastatPF-06865571PF06865571PF 06865571AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferasesteatosishepatic triglyceride NASHNAFLDliver fibrosismonotherapyInhibitorinhibitorinhibit

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