1. Epigenetics
  2. Histone Methyltransferase
  3. EZH2-IN-9

EZH2-IN-9 is a potent inhibitor of EZH2. EZH2 overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) all lead to abnormal elevation of H3K27me3 and promote the growth and development of many types of tumors, such as breast cancer, prostate cancer, leukemia, etc. EZH2-IN-9 has the potential for the research of cancer diseases (extracted from patent WO2021180235A1, compound 17).

For research use only. We do not sell to patients.

EZH2-IN-9 Chemical Structure

EZH2-IN-9 Chemical Structure

CAS No. : 2700897-24-9

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Description

EZH2-IN-9 is a potent inhibitor of EZH2. EZH2 overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) all lead to abnormal elevation of H3K27me3 and promote the growth and development of many types of tumors, such as breast cancer, prostate cancer, leukemia, etc. EZH2-IN-9 has the potential for the research of cancer diseases (extracted from patent WO2021180235A1, compound 17)[1].

Molecular Weight

596.09

Formula

C28H32ClF2N3O5S

CAS No.
SMILES

CC1=C2C(OC(O2)([C@]3([H])CC[C@H](CC3)C(N4CC(F)(C4)F)=O)C)=C(C=C1C(NCC5=C(C=C(NC5=O)C)SC)=O)Cl

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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EZH2-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
EZH2-IN-9
Cat. No.:
HY-144094
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