2. PI3K/Akt/mTOR
    Apoptosis
  3. Akt
    Apoptosis
  4. FPA-124

FPA-124 

Cat. No.: HY-15369 Purity: ≥95.0%
COA Handling Instructions

FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis.

For research use only. We do not sell to patients.

FPA-124 Chemical Structure

FPA-124 Chemical Structure

CAS No. : 902779-59-3

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5 mg USD 300 In-stock
10 mg USD 500 In-stock
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Description

FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis[1][2].

In Vitro

FPA-124 exhibits dose-dependent growth inhibitory effects with IC50s of 7, 10, 34, and 55 μM in BT20, PC-3, COLO 357 and BxPC-3 cancer cell lines, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

FPA-124 exhibits PKB (Akt protein) inhibitory activities and causes NF-κB inactivation in a well-established orthotopic pancreatic tumor model using COLO 357 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

381.73

Appearance

Solid

Formula

C11H9Cl2CuN3O2S
CAS No.
SMILES

O=C1C2=CC=CC=C2OC=C1/C=[N]3[Cu]([Cl-])([S]=C(N)N\3)[Cl-].[2+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (13.10 mM; ultrasonic and warming and heat to 60°C)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6197 mL 13.0983 mL 26.1965 mL
5 mM 0.5239 mL 2.6197 mL 5.2393 mL
10 mM 0.2620 mL 1.3098 mL 2.6197 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.67 mg/mL (1.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 0.67 mg/mL (1.76 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥95.0%

COA (249 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

FPA-124902779-59-3FPA124FPA 124AktApoptosisPKBProtein kinase BcoppercomplexpleckstrinhomologyapoptosisgrowthinhibitorycancerNF-κBInhibitorinhibitorinhibit

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