1. Apoptosis
  2. Apoptosis
    Caspase
  3. Frondoside A

Frondoside A 

Cat. No.: HY-135896
Handling Instructions

Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa, possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.

For research use only. We do not sell to patients.

Frondoside A Chemical Structure

Frondoside A Chemical Structure

CAS No. : 127367-76-4

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Description

Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa, possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety[1][2].

IC50 & Target[2]

Caspase 3

 

Caspase-7

 

In Vitro

Frondoside A (0-5 μM, 24 hours)causes concentration-dependent reduction in viability of lung and breast cancer cells through a caspase 3/7-dependent cell death pathway[2].

Cell Viability Assay[2]

Cell Line: LNM35, A549, NCI-H460-Luc2, MDA-MB-435, MCF-7, and HepG2 cells.
Concentration: 0-5 μM.
Incubation Time: 24 hours.
Result: Significantly and concentration-dependently inhibited cellular viability.

Apoptosis Analysis[2]

Cell Line: LNM35 cells.
Concentration: 1-2.5 μM.
Incubation Time: 24 hours.
Result: Induced caspase-3/7 activity.
In Vivo

Frondoside A (0.01 and 1 mg/kg/ day i.p. for 25 days) significantly decreases the growth, the angiogenesis and lymph node metastasis of LNM35 tumor xenografts in mice, without obvious toxic side-effects[2].

Animal Model: LNM35 xenografts based on Six-week-old athymic NMRI female nude mice (nu/nu)[2].
Dosage: 0.01 and 1 mg/kg.
Administration: IP. daily for 25 days.
Result: Induced regression of established LNM35 xenografts.
Molecular Weight

1335.43

Formula

C₆₀H₉₅NaO₂₉S

CAS No.

127367-76-4

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Frondoside AApoptosisCaspaseInhibitorinhibitorinhibit

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