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Fructose 2,6-biphosphate sodium salt (Synonyms: D-Fructose 2,6-diphosphate sodium salt)

Cat. No.: HY-12314A
Handling Instructions

Fructose 2,6-biphosphate sodium salt is a potent stimulator of 6-Phosphofructo-1-kinase (PFK-1) and also inhibits Fructose-1,6-Bisphosphatase.

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Fructose 2,6-biphosphate sodium salt Chemical Structure

Fructose 2,6-biphosphate sodium salt Chemical Structure

CAS No. : 84364-89-6

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Other Forms of Fructose 2,6-biphosphate sodium salt:

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Description

Fructose 2,6-biphosphate sodium salt is a potent stimulator of 6-Phosphofructo-1-kinase (PFK-1) and also inhibits Fructose-1,6-Bisphosphatase[1].

IC50 & Target

PFK-1, Fructose-1,6-Bisphosphatase[1]

In Vitro

A concentration-dependent inhibition of fructose-1,6-Bisphosphatase by Fructose 2,6-bisphosphate is observed. Another characteristic of this inhibition is that it changes the saturation curve from hyperbolic to sigmoidal. This effect is clearly apparent at 25 pM Fructose 2,6-bisphosphate. It appears that the inhibitory actions of Fructose 2,6-bisphosphate and of AMP are synergistic. Indeed, at 10 pM fructose 1,6-bisphosphate, the addition of AMP alone causes a 35% inhibition but, it increases the inhibition by 1 pM Fructose 2,6-bisphosphate from 20% to 80%[1].

Formula

C₆H₁₄O₁₂P₂.xNa

CAS No.

84364-89-6

SMILES

OC[[email protected]]1(OP(O)(O)=O)[[email protected]@H](O)[[email protected]](O)[[email protected]@H](COP(O)(O)=O)O1.[x Na]

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (Need ultrasonic)

References
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Fructose 2,6-biphosphate sodium salt
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HY-12314A
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