1. Metabolic Enzyme/Protease
    NF-κB
    Immunology/Inflammation
  2. NADPH Oxidase
    Reactive Oxygen Species
  3. Fulvene-5

Fulvene-5 

Cat. No.: HY-12803
Handling Instructions

Fulvene-5 is a potent NADPH oxidase 4 (NOX4) inhibitor with antioxidant properties. Fulvene-5 is a reactive oxygen species (ROS) modifying agent and a potent radioprotector. Fulvene-5 has antitumor activity.

For research use only. We do not sell to patients.

Fulvene-5 Chemical Structure

Fulvene-5 Chemical Structure

CAS No. : 1075723-01-1

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Description

Fulvene-5 is a potent NADPH oxidase 4 (NOX4) inhibitor with antioxidant properties. Fulvene-5 is a reactive oxygen species (ROS) modifying agent and a potent radioprotector. Fulvene-5 has antitumor activity[1][2][3].

IC50 & Target

NADPH oxidase 4 (NOX4)[1]; Reactive oxygen species (ROS)[2]

In Vitro

Fulvene-5 (10 µM; 1 hour) facilitates the reversal of HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures adaptive responses from pro-survival to radio-sensitization and vice versa. These changes are accompanied by corresponding reversals in the translocation of survivin to the nuclei of TP53 WT and to the cytoplasm of TP53 Mut cells. The potential role of NOX4 in the expression of the survivin-associated adaptive response is investigated by transfecting HCT116 cells with NOX4 siRNA oligomers to inhibit NOX4 expression. Under these conditions NOX4 expression is inhibited by about 50%[1].
Fulvene-5 (0.5-1.0 μM) treatment decreases the expression of Ang2, delta-like ligand 4 (DLL4), placental growth factor (PLGF), and Nrarp in a dose-dependent manner in bEnd.3 cells[2].

In Vivo

Fulvene-5 (120 mg/kg/d; intraperitoneal injection; daily; for 2 weeks; nude mice) treatment potently inhibits hemangioma growth in mice[2].

Animal Model: Nude mice injected with bEnd.3 cells[2]
Dosage: 120 mg/kg/d
Administration: Intraperitoneal injection; daily; for 2 weeks
Result: Tumor growth in mice was significantly reduced.
Molecular Weight

358.43

Formula

C₂₆H₁₈N₂

CAS No.

1075723-01-1

SMILES

C1(C/2=C3C=CC=C\3)=CC=CC=C1NC2=C4NC(C=CC=C5)=C5C\4=C6C=CC=C/6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Fulvene-5Fulvene5Fulvene 5NADPH OxidaseReactive Oxygen SpeciesNOXROSNOX4survivinantioxidantDNAdamageradioprotectorNrarpDll4antitumorInhibitorinhibitorinhibit

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