Gadobutrol hydrate (Synonyms: ZK 135079 hydrate)

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Gadobutrol (ZK 135079) hydrate is a nonionic paramagnetic macrocyclic gadolinium-based contrast agent that can be used for magnetic resonance imaging (MRI).

For research use only. We do not sell to patients.

Gadobutrol hydrate Chemical Structure

CAS No. : 198637-52-4

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1 Publications Citing Use of MCE Gadobutrol hydrate

•Molecules. 2021 Aug 24;26(17):5115. [Abstract]

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Description

Gadobutrol (ZK 135079) hydrate is a nonionic paramagnetic macrocyclic gadolinium-based contrast agent that can be used for magnetic resonance imaging (MRI)^[1].

In Vitro

Gadobutrol hydrate leads to a gradual decrease in cell density with increasing concentration under neutron irradiation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Human melanoma cell line Sk-Mel-28
Concentration:	0-30 mM
Incubation Time:	1 hour
Result:	Showed a decrease in cell density to 26% at 30 mM while to 80% with no gadobutrol under neutron irradiation.

In Vivo

Gadobutrol hydrate (intravenous injection, 200 mM, once) can significantly enhance intracerebroventricular cell signaling in female C57BL/6 N mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6 N mice, 11-13 weeks, 21-23 g^[2]
Dosage:	200 mM
Administration:	Intravenous injection; once
Result:	Enhanced cells signal in the habenula, hippocampal formation, and locus coeruleus.

Clinical Trial

Molecular Weight

622.73

Formula

C₁₈H₃₃GdN₄O₁₀

CAS No.

198637-52-4

SMILES

OC[C@H]1[N]23[Gd+3]([N]4(C5)CC3)([N]6(C7)CC4)([OH][C@@H]1CO)([O-]C5=O)([O-]C8=O)([O-]C7=O)[N](CC6)(C8)CC2.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. B Hofmann, et al. Gadolinium neutron capture therapy (GdNCT) of melanoma cells and solid tumors with the magnetic resonance imaging contrast agent Gadobutrol. Invest Radiol. 1999 Feb;34(2):126-33. [Content Brief]

[2]. Takashi Watanabe, et al. Gadobutrol enhances T1-weighted MRI of nerve cells. Toxicol Lett. 2019 Jun 15;308:17-2 [Content Brief]

Gadobutrol hydrate Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gadobutrol198637-52-4ZK 135079ZK135079ZK-135079Biochemical Assay Reagentsontrast agentMRIInhibitorinhibitorinhibit

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