1. GPCR/G Protein
  2. CaSR
  3. Gadolinium chloride

Gadolinium chloride (Synonyms: GdCl3)

Cat. No.: HY-103314 Purity: ≥99.0%
Handling Instructions

Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease.

For research use only. We do not sell to patients.

Gadolinium chloride Chemical Structure

Gadolinium chloride Chemical Structure

CAS No. : 10138-52-0

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Based on 1 publication(s) in Google Scholar

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Description

Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease[1].

IC50 & Target

CaSR[1]

In Vitro

Gadolinium chloride (30 μM; 15 minutes; H9c2 cells) results in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells[1].
In vitro, GdCl3, a CaSR agonist, has been shown to promote the apoptosis of myocardial cells, which increases ERK1/2 phosphorylation and activates caspase-3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: H9c2 cells
Concentration: 30 μM
Incubation Time: 15 minutes
Result: Resulted in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells.
Molecular Weight

263.61

Formula

Cl₃Gd

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

References

Purity: ≥99.0%

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Gadolinium chloride
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HY-103314
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