2. GPCR/G Protein
  3. CaSR
  4. Gadolinium chloride

Gadolinium chloride  (Synonyms: GdCl3)

Cat. No.: HY-103314 Purity: ≥99.0%
COA Handling Instructions

Molarity Calculator

Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease.

For research use only. We do not sell to patients.

Gadolinium chloride Chemical Structure

Gadolinium chloride Chemical Structure

CAS No. : 10138-52-0

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
25 mg USD 50 In-stock
50 mg USD 65 In-stock
100 mg USD 100 In-stock
500 mg USD 280 In-stock
1 g   Get quote  
5 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Gadolinium chloride Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease[1].

IC50 & Target

CaSR[1]
In Vitro

Gadolinium chloride (30 μM; 15 minutes; H9c2 cells) results in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells[1].
In vitro, GdCl3, a CaSR agonist, has been shown to promote the apoptosis of myocardial cells, which increases ERK1/2 phosphorylation and activates caspase-3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gadolinium chloride Related Antibodies

Western Blot Analysis[1]

Cell Line: H9c2 cells
Concentration: 30 μM
Incubation Time: 15 minutes
Result: Resulted in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells.
Molecular Weight

263.61

Formula

Cl3Gd
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

Cl[Gd](Cl)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1M HCl : 100 mg/mL (379.35 mM; ultrasonic and adjust pH to 1 with HCl)

H2O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7935 mL 18.9674 mL 37.9348 mL
5 mM 0.7587 mL 3.7935 mL 7.5870 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M HCl 1 mM 3.7935 mL 18.9674 mL 37.9348 mL 94.8371 mL
5 mM 0.7587 mL 3.7935 mL 7.5870 mL 18.9674 mL
10 mM 0.3793 mL 1.8967 mL 3.7935 mL 9.4837 mL
15 mM 0.2529 mL 1.2645 mL 2.5290 mL 6.3225 mL
20 mM 0.1897 mL 0.9484 mL 1.8967 mL 4.7419 mL
25 mM 0.1517 mL 0.7587 mL 1.5174 mL 3.7935 mL
30 mM 0.1264 mL 0.6322 mL 1.2645 mL 3.1612 mL
40 mM 0.0948 mL 0.4742 mL 0.9484 mL 2.3709 mL
50 mM 0.0759 mL 0.3793 mL 0.7587 mL 1.8967 mL
60 mM 0.0632 mL 0.3161 mL 0.6322 mL 1.5806 mL
80 mM 0.0474 mL 0.2371 mL 0.4742 mL 1.1855 mL
100 mM 0.0379 mL 0.1897 mL 0.3793 mL 0.9484 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Gadolinium chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gadolinium10138-52-0GdCl3GdCl 3GdCl-3CaSRCalcium-sensing receptorspecificcalcium-sensingreceptorcardiovascularH9c2Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Gadolinium chloride
Cat. No.:
HY-103314
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.