1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Galidesivir triphosphate

Galidesivir triphosphate (Synonyms: Immucillin-A triphosphate; BCX4430-triphosphate; BCX6870)

Cat. No.: HY-133331
Handling Instructions

Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir. Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola.

For research use only. We do not sell to patients.

Galidesivir triphosphate Chemical Structure

Galidesivir triphosphate Chemical Structure

CAS No. : 1467740-78-8

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir. Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola[1][2].

In Vitro

In virus-infected cells, Galidesivir is converted to the triphosphate, is incorporated into the viral transcript, and functions as an atypical chain-terminator for RNA-dependent RNA polymerases. Galidesivir is converted to the mono-, di-, and triphosphates in virus-infected human Huh-7 cells[1].
Galidesivir triphosphate (Immucillin-A triphosphate) (1-60 μM) inhibits hepatitis C virus (HCV) RNA polymerase transcriptional activity in a cell-free, isolated enzyme transcription assay.The triphosphate is a substrate for viral RNA-dependent RNA polymerase. Its incorporation permits the addition of a few additional encoded bases at which point the Galidesivir-modified RNA cannot be elongated[2].

In Vivo

In vivo conversion of Galidesivir to its TP (Galidesivir triphosphate) nucleotide is particularly efficient[3]

Molecular Weight

505.21

Formula

C₁₁H₁₈N₅O₁₂P₃

CAS No.

1467740-78-8

SMILES

O=P(O)(OP(O)(OP(O)(O)=O)=O)OC[[email protected]]1N[[email protected]@H](C2=CNC3=C(N)N=CN=C32)[[email protected]](O)[[email protected]@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Galidesivir triphosphateImmucillin-A triphosphateBCX4430-triphosphateBCX6870BCX 6870BCX-6870DNA/RNA SynthesisprodrugterminationviralRNAreplicationHCVNS5BEbolainfectiousInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Galidesivir triphosphate
Cat. No.:
HY-133331
Quantity:
MCE Japan Authorized Agent: