2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. Garsorasib

Garsorasib is a potent inhibitor of KRAS G12C with an IC50 of 10 nM. Garsorasib has the potential for the research of various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (non-small cell lung cancer) (extracted from patent WO2020233592A1, compound 2).

For research use only. We do not sell to patients.

Garsorasib Chemical Structure

Garsorasib Chemical Structure

CAS No. : 2559761-14-5

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5 mg USD 395 In-stock
10 mg USD 620 In-stock
25 mg USD 1150 In-stock
50 mg USD 1850 In-stock
100 mg USD 2960 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Garsorasib is a potent inhibitor of KRAS G12C with an IC50 of 10 nM. Garsorasib has the potential for the research of various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (non-small cell lung cancer) (extracted from patent WO2020233592A1, compound 2)[1].

IC50 & Target

KRas G12C

 

Molecular Weight

598.65

Formula

C32H32F2N8O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C2=NC(C3=C(C=CC=C3N)F)=C(F)C=C2C(N4[C@H](CN([C@@H](C4)C)C(C=C)=O)C)=N1)C5=C(C6CC6)N=CN=C5C7CC7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (167.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6704 mL 8.3521 mL 16.7043 mL
5 mM 0.3341 mL 1.6704 mL 3.3409 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6704 mL 8.3521 mL 16.7043 mL 41.7606 mL
5 mM 0.3341 mL 1.6704 mL 3.3409 mL 8.3521 mL
10 mM 0.1670 mL 0.8352 mL 1.6704 mL 4.1761 mL
15 mM 0.1114 mL 0.5568 mL 1.1136 mL 2.7840 mL
20 mM 0.0835 mL 0.4176 mL 0.8352 mL 2.0880 mL
25 mM 0.0668 mL 0.3341 mL 0.6682 mL 1.6704 mL
30 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3920 mL
40 mM 0.0418 mL 0.2088 mL 0.4176 mL 1.0440 mL
50 mM 0.0334 mL 0.1670 mL 0.3341 mL 0.8352 mL
60 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6960 mL
80 mM 0.0209 mL 0.1044 mL 0.2088 mL 0.5220 mL
100 mM 0.0167 mL 0.0835 mL 0.1670 mL 0.4176 mL
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Garsorasib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Garsorasib2559761-14-5D-1553D1553D 1553RasKRAS G12Canti-cancernon-small cell lung cancerpancreatic cancerendometrial cancercolorectal cancerInhibitorinhibitorinhibit

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