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Gd-NMC-3 

Cat. No.: HY-150979
Handling Instructions

Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential.

For research use only. We do not sell to patients.

Gd-NMC-3 Chemical Structure

Gd-NMC-3 Chemical Structure

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Description

Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential[1].

In Vitro

Gd-NMC-3 shows the maximum excitation wavelength and emission wavelength are 755 and 792 nm, respectively. Both wavelengths are located in the near-infrared region[1].
Gd-NMC-3 acts as a bimodal imaging molecule, can be accumulated in tumor sites[1].
Gd-NMC-3 (50 μM; 24 h) can be internalized into cancer cells by OATPs and NTCP, indicating an excellent specificity to tumor tissues[1].
Gd-NMC-3 (6.25-800 μM, 24 h) exhibits significant fluorescence accumulation (with the optimal concentration of 100, 200 μM) and reasonable relaxation property (11.64 M/m/s) in tumors[1].
Gd-NMC-3 (6.25-100 μM, 48 h) displays low cytotoxicity and good biocompatibility[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 and LM3: human hepatocarcinoma cell line; L02: human hepatocyte cell line
Concentration: 6.25-100 μM
Incubation Time: 48 hours
Result: Resulted more than 90% cell viability maintained after 48 h.
In Vivo

Gd-NMC-3 (20 mg/kg; i.v.) holds an excellent tumor targeting ability, shows high resolution and sensitivity and provides real-time visual navigation in LM3 orthotopic and subcutaneous tumor models to guide the resection of tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HepG2 subcutaneous xenograft mice[1]
Dosage: 20 mg/kg
Administration: Intravenous injection; 1.5 h later dissected tumors
Result: Accumulated in the tumor after injection and produced stronger fluorescence intensity in tumor tissues.
Remained fluorescence signal longer than 1.5 h, and provided high-resolution images of the tumor tissues with a SNR of 4.32.
Animal Model: LM3 orthotopic mice[1]
Dosage: 20 mg/kg
Administration: Intravenous injection
Result: Decreased gradually the fluorescence intensity in LM3 orthotopic liver tumors after administration, whereas tumor-to-skin fluorescence ratios increased due to high accumulation and low clearance in tumor tissues.
Molecular Weight

1968.46

Formula

C77H116Gd2N14O22S2

SMILES

CC1(C)C(/C=C/C=C/C=C/C=C2N(CCCCS(=O)(O)=O)C(C=CC(C(NCCCCNC(CN(CCN(CCN3CC(O)=O)CC(O)=O)CCN(CC3)CC(O)=O)=O)=O)=C4)=C4C/2(C)C)=[N+](CCCCS(=O)([O-])=O)C5=C1C=C(C(NCCCCNC(CN6CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC6)=O)=O)C=C5.[Gd].[Gd]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Gd-NMC-3
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HY-150979
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