2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. Gemnelatinib

Gemnelatinib  (Synonyms: GST-HG161)

Cat. No.: HY-132816 Purity: 99.72% ee.: 100.00%
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Gemnelatinib is a tyrosine kinase inhibitor (WO2018077227, implementation example 1). Gemnelatinib can be used for the research of cancer.

For research use only. We do not sell to patients.

Gemnelatinib Chemical Structure

Gemnelatinib Chemical Structure

CAS No. : 2225123-30-6

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5 mg USD 480 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2600 In-stock
100 mg USD 4000 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Gemnelatinib Related Antibodies

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Description

Gemnelatinib is a tyrosine kinase inhibitor (WO2018077227, implementation example 1). Gemnelatinib can be used for the research of cancer[1].

IC50 & Target

tyrosine kinase[1]
In Vitro

Gemnelatinib is a tyrosine kinase inhibitor[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gemnelatinib Related Antibodies
Molecular Weight

524.59

Formula

C30H29FN6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](C1=CC(C2=NC=C(OCC3CCN(CC3)C)C=N2)=CC=C1)N4C=C(C5=CC(C#N)=CC=N5)C=C(C4=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (19.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9063 mL 9.5313 mL 19.0625 mL
5 mM 0.3813 mL 1.9063 mL 3.8125 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9063 mL 9.5313 mL 19.0625 mL 47.6563 mL
5 mM 0.3813 mL 1.9063 mL 3.8125 mL 9.5313 mL
10 mM 0.1906 mL 0.9531 mL 1.9063 mL 4.7656 mL
15 mM 0.1271 mL 0.6354 mL 1.2708 mL 3.1771 mL
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Gemnelatinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gemnelatinib2225123-30-6GST-HG161c-Met/HGFRInhibitorinhibitorinhibit

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