2. GPCR/G Protein
    Neuronal Signaling
  3. Dopamine Receptor
  4. GR 103691

GR 103691 

Cat. No.: HY-101382 Purity: 99.95%
COA Handling Instructions

GR 103691 is a potent, selective dopamine D3 receptor antagonist with a Ki value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites.

For research use only. We do not sell to patients.

GR 103691 Chemical Structure

GR 103691 Chemical Structure

CAS No. : 162408-66-4

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 85 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 85 In-stock
Solid
5 mg USD 77 In-stock
10 mg USD 132 In-stock
25 mg USD 275 In-stock
50 mg USD 440 In-stock
100 mg USD 715 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

GR 103691 is a potent, selective dopamine D3 receptor antagonist with a Ki value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites[1].

IC50 & Target

Ki: 0.4 nM (Human dopamine D3 receptor)[1]
In Vitro

GR 103691 shows marked affinity for serotonin1A (5-HT1A) receptors (Ki of 5.8 nM) and α-1 adrenoceptors (Ki of 12.6 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

485.62

Appearance

Solid

Formula

C30H35N3O3
CAS No.
SMILES

O=C(C1=CC=C(C2=CC=C(C(C)=O)C=C2)C=C1)NCCCCN3CCN(C4=CC=CC=C4OC)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.30 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0592 mL 10.2961 mL 20.5922 mL
5 mM 0.4118 mL 2.0592 mL 4.1184 mL
10 mM 0.2059 mL 1.0296 mL 2.0592 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.95%

COA (244 KB) HNMR (279 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GR 103691162408-66-4GR103691GR-103691Dopamine ReceptorInhibitorinhibitorinhibit

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