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  3. TCS2002

TCS2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS2002 shows good pharmacokinetic profiles including favorable BBB penetration. TCS2002 can be used for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

TCS2002 Chemical Structure

TCS2002 Chemical Structure

CAS No. : 1005201-24-0

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Based on 1 publication(s) in Google Scholar

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Description

TCS2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS2002 shows good pharmacokinetic profiles including favorable BBB penetration. TCS2002 can be used for the research of Alzheimer’s disease[1].

IC50 & Target[1]

GSK-3

35 nM (IC50)

In Vivo

TCS2002 (Compound 9b) (1-3 mg/kg;1-24 hours; GS rats andC57BL/6N mice) exhibits good pharmacokinetic profiles and favor able BBB permeability with AUC0-24h value is 734 ng•h/g and Kp value (ratio of brain and plasma) is 1.6[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IGS rats (male, 8 weeks old)[1]
Dosage: 1 and 3mg/kg
Administration: Intravenous injection and oral administration;for 1, 2, 4, 8, 24 hours.
Result: 1.19
comp (S)-9b (S)-9c
VDSS,iv (mL/kg) 1134 1650
CLtotal,iv (mL/min/kg) 27.4 28.4
Cmax,po (ng/mL) 396.9 289.6
AUC0-24 h,po (ng·h/mL) 1380.6 1229.1
MRTpo (h) 2.19 3.03
Fd (%) 72.8 65.5
Molecular Weight

338.38

Formula

C18H14N2O3S

CAS No.
SMILES

O=S(C)C1=CC=C(C=C1)C2=COC3=CC=C(C4=NN=C(C)O4)C=C23

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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TCS2002 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TCS2002
Cat. No.:
HY-10096
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