1. Alkaloid
  2. Guanfu base I

Guanfu base I (Synonyms: Acorine)

Cat. No.: HY-N5004
Handling Instructions

Guanfu base I (Acorine) is an active metabolite of Guanfu base A, isolated from Aconitum coreanum, and has a potent anti-arrhythmic effect.

For research use only. We do not sell to patients.

Guanfu base I Chemical Structure

Guanfu base I Chemical Structure

CAS No. : 110225-59-7

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Description

Guanfu base I (Acorine) is an active metabolite of Guanfu base A, isolated from Aconitum coreanum, and has a potent anti-arrhythmic effect[1].

In Vivo

The pharmacokinetics of Guanfu base I in Sprague-Dawley rats is examined. The method is linear in the 0.05-20 μg/mL concentration range. The recovery of Guanfu base I is more than 80%. The intraday and interday precision, expressed as the relative standard deviation, is generally good. After intravenous injection dosing, plasma Guanfu base I concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 hours. The total plasma clearance value is 1.46 L/h/kg. After oral dosing, the plasma Guanfu base I concentration reached a maximum within 0.5 hour. The absolute bioavailability of Guanfu base I is 71.31%[1].

Molecular Weight

387.47

Formula

C₂₂H₂₉NO₅

CAS No.

110225-59-7

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Guanfu base IAcorineOthersInhibitorinhibitorinhibit

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