Halichondrin B

Cat. No.: HY-N10536: FAQs
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Halichondrin B is found from the sponge Halichondria okadai. Halichondrin B is a noncompetitive inhibitor of Vinca-alkaloid binding to tubulin (IC₅₀ for tubulin polymerization of 1.2-1.4 μM). Halichondrin B shows anti-tumor activity.

For research use only. We do not sell to patients.

Halichondrin B Chemical Structure

CAS No. : 103614-76-2

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Description

In Vitro

Halichondrin B (0.1-10 nM, 16 h) treatment inhibits the growth of L1210 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	L1210 cells
Concentration:	0.1-10 nM
Incubation Time:	16 hours
Result:	Inhibited L1210 cell with IC₅₀ value of 0.3 nM.

Molecular Weight

1111.31

Formula

C₆₀H₈₆O₁₉

CAS No.

103614-76-2

SMILES

C[C@@H]1[C@]2([H])O[C@]3(O[C@@](C[C@@](O[C@](C[C@@](C([C@@H]4C)=C)([H])O[C@@](C4)([H])CC[C@]5([H])O[C@](CC6)([H])CC5=C)([H])[C@@](OC(C[C@]7([H])O[C@]8([H])[C@@](O[C@@]6(C9)O[C@@]%10([H])[C@]9([H])O%11)([H])[C@@]%11([H])[C@@]%10([H])O[C@@]8([H])CC7)=O)([H])[C@H]%12C)([H])[C@@]%12([H])O%13)([H])[C@@]%13([H])C3)C[C@]2([H])O[C@](O[C@](C[C@@]%14([H])[C@@H](O)C[C@@H](O)CO)([H])[C@](O%14)([H])[C@H]%15C)(C%15)C1

Structure Classification

Others

Initial Source

Animals

Halichondria okadai Kadota

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J Biol Chem. 1991 Aug 25;266(24):15882-9. [Content Brief]

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Halichondrin B103614-76-2OthersHalichondria okadaiVinca-alkaloid binding to tubulinanti-tumor activityL1210Inhibitorinhibitorinhibit

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