2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. hCA IX-IN-2

hCA IX-IN-2 is a potent and selectively hCA IX inhibitor with an KI value of 32.1 nM. hCA IX-IN-2 shows anti-proliferative activity.

For research use only. We do not sell to patients.

hCA IX-IN-2 Chemical Structure

hCA IX-IN-2 Chemical Structure

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hCA IX-IN-2 Related Antibodies

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Description

hCA IX-IN-2 is a potent and selectively hCA IX inhibitor with an KI value of 32.1 nM. hCA IX-IN-2 shows anti-proliferative activity[1].

IC50 & Target

hCA IX

32.1 nM (Ki)

hCA XII

8.1 nM (Ki)

hCA VII

15.9 nM (Ki)

hCA XIII

95.7 nM (Ki)

In Vitro

hCA IX-IN-2 (compound 7c) (0-100 μM; 24 h) shows anti-proliferative activity with IC50s of 62.5, 0.7121, 12.11, 7.834, 2.356 μM for HDF, MeWo, LN-229, SaOS-2, HepG2 cells, respectively[1].
hCA IX-IN-2 (62.5 μM for NHDF, 2.365 μM for HepG2) induces a significant decrease in O2•- production in NHDF and HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

hCA IX-IN-2 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: NHDF, MeWo, LN-229, SaOS-2, HepG2 cells
Concentration: 0, 5, 10, 30, 70, 100 μM
Incubation Time: 24 h
Result: Inhibited cell growth with IC50s of 62.5, 0.7121, 12.11, 7.834, 2.356 μM for HDF, MeWo, LN-229, SaOS-2, HepG2 cells, respectively.
Molecular Weight

552.11

Formula

C23H24N2O4STe
SMILES

COC1=CC=C(C=C1)[Te]CC2=CC=C(C=C2)C(NCCC3=CC=C(C=C3)S(N)(=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hCA IX-IN-2 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCA IX-IN-2Carbonic AnhydraseCarbonate dehydrataseanti-proliferativeNHDFHepG2 cellsO2H2O2antitumorInhibitorinhibitorinhibit

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Product Name:
hCA IX-IN-2
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HY-152001
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