1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase
  3. HIF-1 inhibitor-1

HIF-1 inhibitor-1 

Cat. No.: HY-128779
Handling Instructions

HIF-1 inhibitor-1 is an aryl carboxamide compound and a potent hypoxia-inducible factor 1 (HIF-1) inhibitor with an IC50 of 0.32 μM for the cancer metastasi.

For research use only. We do not sell to patients.

HIF-1 inhibitor-1 Chemical Structure

HIF-1 inhibitor-1 Chemical Structure

CAS No. : 2380261-53-8

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Description

HIF-1 inhibitor-1 is an aryl carboxamide compound and a potent hypoxia-inducible factor 1 (HIF-1) inhibitor with an IC50 of 0.32 μM for the cancer metastasi[1].

IC50 & Target

IC50: 0.32 μM (HIF-1)[1]

In Vitro

HIF-1 inhibitor-1 (compound 30m) effectively attenuates hypoxia-induced HIF-1α protein accumulation and reduces transcription of vascular epidermal growth factor in a dose-dependent manner[1].

In Vivo

HIF-1 inhibitor-1 (compound 30m) exhibits antimetastatic potency in breast cancer lung metastasis in the mice model, indicating its promising therapeutic potential for prevention and treatment of tumor metastasis[1].

Molecular Weight

350.39

Formula

C₂₁H₁₉FN₂O₂

CAS No.

2380261-53-8

SMILES

COC1=CC=CC=C1C2=CN=C(C(NCCC3=CC=CC=C3F)=O)C=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

HIF-1 inhibitor-1HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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HIF-1 inhibitor-1
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