1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase
  3. HIF-2α-IN-3

HIF-2α-IN-3 

Cat. No.: HY-18370 Purity: 99.52%
Handling Instructions

HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent.

For research use only. We do not sell to patients.

HIF-2α-IN-3 Chemical Structure

HIF-2α-IN-3 Chemical Structure

CAS No. : 313964-19-1

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent[1].

IC50 & Target

IC50: 0.4 µM (HIF-2α)[1]
KD: 1.1 µM (HIF-2α)[1]

In Vitro

HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

335.66

Formula

C₁₂H₆ClN₅O₅

CAS No.

313964-19-1

SMILES

O=[N+](C1=C(NC2=CC=C(Cl)C([N+]([O-])=O)=C2)C=CC3=NON=C31)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (37.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9792 mL 14.8960 mL 29.7921 mL
5 mM 0.5958 mL 2.9792 mL 5.9584 mL
10 mM 0.2979 mL 1.4896 mL 2.9792 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

HIF-2α-IN-3HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHypoxiaproteinligandinteractioncancerInhibitorinhibitorinhibit

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Product Name:
HIF-2α-IN-3
Cat. No.:
HY-18370
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