1. Others Epigenetics PI3K/Akt/mTOR
  2. Oxidative Phosphorylation AMPK
  3. Lixumistat hydrochloride

Lixumistat hydrochloride  (Synonyms: HL271; IM156 hydrochloride; HL156A hydrochloride)

Cat. No.: HY-136093
Handling Instructions

Lixumistat (HL271) hydrochloride (IM156 hydrochloride; HL156A hydrochloride), a chemical derivative of Metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. Lixumistat hydrochloride attenuates aging-associated cognitive impairment in animal model. Lixumistat hydrochloride is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Lixumistat acetate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Lixumistat hydrochloride Chemical Structure

Lixumistat hydrochloride Chemical Structure

CAS No. : 1422365-52-3

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Description

Lixumistat (HL271) hydrochloride (IM156 hydrochloride; HL156A hydrochloride), a chemical derivative of Metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. Lixumistat hydrochloride attenuates aging-associated cognitive impairment in animal model[1][2]. Lixumistat hydrochloride is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors[3].

IC50 & Target

AMPK[1][2], OXPHOS[3]

In Vitro

Lixumistat hydrochloride (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells[1].
Lixumistat hydrochloride does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: NIH3T3 cells
Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time: 4 hours
Result: Significantly increased the AMPK phosphorylation rate.
In Vivo

Lixumistat (hydrochloride) does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity[1].
Lixumistat (hydrochloride) (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety[2].
Lixumistat (hydrochloride) significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory[2].
Lixumistat (hydrochloride) significantly increases AMPK activation in the hippocampus of aged mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (young group/12-16 weeks, old groups/20-22 months)[2]
Dosage: 50 mg/kg
Administration: Oral administration (in drinking water), for 2 months
Result: Attenuated age-related cognitive decline.
Clinical Trial
Molecular Weight

351.76

Formula

C13H17ClF3N5O

CAS No.
SMILES

N=C(N1CCCC1)NC(NC2=CC=C(OC(F)(F)F)C=C2)=N.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Lixumistat hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Lixumistat hydrochloride
Cat. No.:
HY-136093
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