1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK
  3. HL271

HL271 

Cat. No.: HY-136093
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HL271, a chemical derivative of metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.

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HL271 Chemical Structure

HL271 Chemical Structure

CAS No. : 1422365-52-3

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Description

HL271, a chemical derivative of metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment[1][2].

IC50 & Target

AMPK[1][2]

In Vitro

HL271 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells[1].
HL271 does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1)[1].

Western Blot Analysis[1]

Cell Line: NIH3T3 cells
Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time: 4 hours
Result: Significantly increased the AMPK phosphorylation rate.
In Vivo

HL271 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity[1].
HL271 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety[2].
HL271 significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory[2].
HL271 significantly increases AMPK activation in the hippocampus of aged mice[2].

Animal Model: C57BL/6J mice (young group/12~16 weeks, old groups/20~22 months)[2]
Dosage: 50 mg/kg
Administration: Oral administration (in drinking water), for 2 months
Result: Attenuated age-related cognitive decline.
Molecular Weight

351.76

Formula

C₁₃H₁₇ClF₃N₅O

CAS No.

1422365-52-3

SMILES

N=C(N1CCCC1)NC(NC2=CC=C(OC(F)(F)F)C=C2)=N.[H]Cl

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Keywords:

HL271HL 271HL-271AMPKAMP-activated protein kinaseMetforminDementiaalzheimerdiseasecognitivefunctionmemoryage-relateddeclineInhibitorinhibitorinhibit

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HL271
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HY-136093
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