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Signaling Pathway

I-BET151

HY-13235

(GSK1210151A; I-BET 151; GSK-1210151A; GSK 1210151A)

I-BET151

I-BET151 Chemical Structure

I-BET151(GSK1210151A) is a BET bromodomain inhibitor(pIC50=6.1,BRD4); I-BET151 blocks recruitment of BET to chromatin .

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $110 In-stock
5 mg $100 In-stock
10 mg $120 In-stock
50 mg $360 In-stock
100 mg $630 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €108 In-stock
5 mg €98 In-stock
10 mg €118 In-stock
50 mg €353 In-stock
100 mg €617 In-stock
200 mg Get quote
500 mg Get quote

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Product name: I-BET151
Cat. No.: HY-13235

I-BET151 Data Sheet

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    Purity: 99.19%

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Related Compound Libraries

Biological Activity of I-BET151

I-BET151(GSK1210151A) is a BET bromodomain inhibitor(pIC50=6.1,BRD4); I-BET151 blocks recruitment of BET to chromatin .
IC50 value: 6.1(pIC50) [1]
Target: BET bromodomain
I-BET151 induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively). I-BET151 reduces BCL2 expression in NOMO1 cells. I-BET151 improves survival in two rodents models of MLL-fusion leukemia in vivo.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 415.44 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C23H21N5O3
CAS No 1300031-49-5
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.4071 mL 12.0354 mL 24.0709 mL
5 mM 0.4814 mL 2.4071 mL 4.8142 mL
10 mM 0.2407 mL 1.2035 mL 2.4071 mL

References on I-BET151

Inhibitor Kit
  • ARV-825

    ARV-825 is a BRD4 inhibitor with DC50 (50% of maximum degradation) <1nM for Burkitt(acute)s lymphoma (BL) cell lines. Affinity to BD1 and BD2 of BRD4 by ARV-825 is 90 and 28 nM, respectively.

  • BET-BAY 002

    BET-BAY 002 is a potent BET inhibitor; shows efficacy in a multiple myeloma model.

  • BI 2536

    BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM, BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3; BI2536 also is a BRD4 inhibitor(IC50= 25 nM).

  • BI-7273

    BI-7273 is a selective, and cell-permeable BRD9 BD inhibitor.

  • BI-9564

    BI-9564 is a selective, and cell-permeable BRD9 BD inhibitor, with Kd of 5.9 nM for BRD9, and IC50 of > 100 (mu)M for BET family.

  • Bromosporine

    Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 (mu)M, 0.29 (mu)M, 0.122 (mu)M and 0.017 (mu)M for BRD2, BRD4, BRD9 and CECR2, respectively.

  • CPI-203

    CPI 203 is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~37 nM (BRD4 (alpha)-screen assay).

  • CPI-360

    CPI-360 is a potent, selectiveEZH2inhibitor with IC50 of 0.5 nM and 2.5 nM nM for wt EZH2 and Y641N EZH2, respectively.

  • EI1

    EI1 is a potent and selective small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively.

  • EPZ005687

    EPZ-005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.

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