1. NF-κB
  2. IKK
  3. IKKβ-IN-1

IKKβ-IN-1 

Cat. No.: HY-146723
Handling Instructions

IKKβ-IN-1 is a potent and orally active IkappaB (IKK-β) inhibitor with IC50 of 0.20 μM. IKKβ-IN-1 can reduce PGE2 and TNF-α production in mouse macrophage cells. IKKβ-IN-1 has the ability to protect mice against septic shock induced mortality.

For research use only. We do not sell to patients.

IKKβ-IN-1 Chemical Structure

IKKβ-IN-1 Chemical Structure

CAS No. : 2410423-31-1

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Description

IKKβ-IN-1 is a potent and orally active IkappaB (IKK-β) inhibitor with IC50 of 0.20 μM. IKKβ-IN-1 can reduce PGE2 and TNF-α production in mouse macrophage cells. IKKβ-IN-1 has the ability to protect mice against septic shock induced mortality[1].

IC50 & Target[1]

IKK-β

0.2 (IC50)

In Vitro

IKKβ-IN-1 (compound 7a) (0.1, 1 and 10 μM; 24 hours) does not show significant cytotoxicity at the tested three concentrations[1].
IKKβ-IN-1 (0.1, 1 and 10 μM; 1 hours) significantly reduces PGE2 production even at the low 0.1 μM concentration, and IC50 is 9.83 μM[1].
IKKβ-IN-1 (0.1, 1 and 10 μM; 1 hours) elicits 44% reduction of TNF-α production at 10 μM concentration, and IC50 is 6.27 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line: RAW 264.7 macrophage cells[1]
Concentration: 0.1, 1 and 10 μM
Incubation Time: 24 hours
Result: Did not show significant cytotoxicity at the tested three concentrations.
In Vivo

IKKβ-IN-1 (5 or 50 mg/kg; PO, single) exhibits an efficient protection of LPS-induced production of the inflammatory mediators at both of the two administered doses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 male mice (6 or 10 weeks; LPS-induced production of the inflammatory mediators)[1]
Dosage: 5 or 50 mg/kg
Administration: PO, single (1 hour before LPS injection; survival was monitored for 36 hours)
Result: Exhibited an efficient protection of LPS-induced production of the inflammatory mediators at both of the two administered doses.
Molecular Weight

554.66

Formula

C31H30N4O4S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
IKKβ-IN-1
Cat. No.:
HY-146723
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