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  2. TNF Receptor Bacterial
  3. Infliximab

Infliximab  (Synonyms: Avakine; CT-P13)

Cat. No.: HY-P9970 Purity: 90.30%
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Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research.

For research use only. We do not sell to patients.

Infliximab Chemical Structure

Infliximab Chemical Structure

CAS No. : 170277-31-3

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Customer Review

Based on 8 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Infliximab purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 May.

    Infliximab (IFX; 10 mg/kg; i.p.; single) significantly increases the number of RGCs in mice.

    Infliximab purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 May.

    Infliximab (IFX; 10 mg/kg; i.p.; single) decreases the p-p38/p38 level in NMDA-induced RGC injury mouse retinas.
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    • Customer Review

    Description

    Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research[1][2].

    In Vitro

    TNF-α-treated adipocytes shows a significant 64% decrease in insulin-stimulated glucose uptake, whereas Infliximab (10 ng/mL) reverses TNF-α actions by significantly improving glucose incorporation in 3T3L1 adipocytes. Infliximab restores phosphorylation of substrate-2 and AKT by attenuating protein-tyrosine phosphatase 1B (PTP1B) activation. Infliximab ameliorates TNF-α-induced insulin resistance in 3T3L1 adipocytes in vitro by restoring the insulin signalling pathway via PTP1B inhibition[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    A single injection of Infliximab (10 μg/g in 100 μl saline/dose ip) in diabetic TNF-α+/+) mice leads to suppression of the increased serum TNF-α and amelioration of the electrophysiological and biochemical deficits for at least 4 weeks. The increased TNF-α mRNA expression in diabetic dorsal root ganglion is also attenuated by Infliximab[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [Avakine]

    Shipping

    Shipping with dry ice.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation

    Purity: 90.30%

    References
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    Infliximab Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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