1. Anti-infection
  2. Influenza Virus
  3. Influenza A virus-IN-7

Influenza A virus-IN-7 

Cat. No.: HY-146361
Handling Instructions

Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and CC50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA.

For research use only. We do not sell to patients.

Influenza A virus-IN-7 Chemical Structure

Influenza A virus-IN-7 Chemical Structure

CAS No. : 2464415-40-3

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Description

Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and CC50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA[1].

IC50 & Target

IC50: 3.43 µM (influenza virus); CC50: >100 µM (influenza virus)[1]

In Vivo

Influenza A virus-IN-7 (compound 16r) (1.25 mg/kg for i.v.; 25 mg/kg for p.o.) shows good PK profiles with oral bioavailability of 22.5%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SD rats[1]
Dosage: 1.25, 25 mg/kg
Administration: I.v. or p.o
Result: Showed good PK profiles with oral bioavailability of 22.5%.
Molecular Weight

459.54

Formula

C29H25N5O

CAS No.
SMILES

O=C(NC1=CC=C2C=CC=CC2=C1)CNC3=NC(N4CCC5=C(C4)C=CC=C5)=NC6=CC=CC=C63

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Influenza A virus-IN-7
Cat. No.:
HY-146361
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