2. PI3K/Akt/mTOR Anti-infection
  3. PI4K Parasite
  4. KDU731

KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo. KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety.

For research use only. We do not sell to patients.

KDU731 Chemical Structure

KDU731 Chemical Structure

CAS No. : 1610610-48-4

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Based on 1 publication(s) in Google Scholar

KDU731 Related Antibodies

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  • Biological Activity

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Description

KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo[1][2]. KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety[2].

IC50 & Target[1] [1]

PI4K

 

In Vivo

KDU731 (orally administration; 7 or 10mg/kg; 16 days) has potent activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding[2].
KDU731 (orally administration; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed significantly fewer oocysts than vehicle treated calves in their stool[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 week old C57BL/6 IFN-γ-knockout mice with 10,000 oocysts[1]
Dosage: 7 or 10 mg/kg
Administration: Orally administration; 7 or 10 mg/kg; 16 days
Result: Resulted in significant reduction of oocyst shedding.
Animal Model: Neonatal calves with 5 x 107 oocysts[1]
Dosage: 5 mg/kg
Administration: Orally administration; 5 mg/kg; every 12 hours for 7 days
Result: Resulted in significant reduction of oocyst shedding in treated calves in their stool.
Molecular Weight

396.40

Formula

C22H16N6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC2=C(C3=CC=C(C(N)=O)C=C3)C=NN2C=C1)N(C)C4=NC=C(C#N)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (210.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5227 mL 12.6135 mL 25.2270 mL
5 mM 0.5045 mL 2.5227 mL 5.0454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5227 mL 12.6135 mL 25.2270 mL 63.0676 mL
5 mM 0.5045 mL 2.5227 mL 5.0454 mL 12.6135 mL
10 mM 0.2523 mL 1.2614 mL 2.5227 mL 6.3068 mL
15 mM 0.1682 mL 0.8409 mL 1.6818 mL 4.2045 mL
20 mM 0.1261 mL 0.6307 mL 1.2614 mL 3.1534 mL
25 mM 0.1009 mL 0.5045 mL 1.0091 mL 2.5227 mL
30 mM 0.0841 mL 0.4205 mL 0.8409 mL 2.1023 mL
40 mM 0.0631 mL 0.3153 mL 0.6307 mL 1.5767 mL
50 mM 0.0505 mL 0.2523 mL 0.5045 mL 1.2614 mL
60 mM 0.0420 mL 0.2102 mL 0.4205 mL 1.0511 mL
80 mM 0.0315 mL 0.1577 mL 0.3153 mL 0.7883 mL
100 mM 0.0252 mL 0.1261 mL 0.2523 mL 0.6307 mL
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KDU731 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KDU7311610610-48-4KDU 731KDU-731PI4KParasitePhosphatidylinositol 4 kinasesPI4 kinasesInhibitorinhibitorinhibit

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