1. NF-κB
  2. Keap1-Nrf2
  3. Keap1-Nrf2-IN-1 TFA

Keap1-Nrf2-IN-1 TFA 

Cat. No.: HY-126245A
Handling Instructions

Keap1-Nrf2-IN-1 TFA (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1-Nrf2-IN-1 TFA activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models.

For research use only. We do not sell to patients.

Keap1-Nrf2-IN-1 TFA Chemical Structure

Keap1-Nrf2-IN-1 TFA Chemical Structure

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Description

Keap1-Nrf2-IN-1 TFA (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1-Nrf2-IN-1 TFA activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models[1].

IC50 & Target

IC50: 43 nM (Keap1 protein)[1]

Molecular Weight

598.54

Formula

C₂₆H₂₅F₃N₂O₉S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (139.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6707 mL 8.3537 mL 16.7073 mL
5 mM 0.3341 mL 1.6707 mL 3.3415 mL
10 mM 0.1671 mL 0.8354 mL 1.6707 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Keap1-Nrf2-IN-1 TFA
Cat. No.:
HY-126245A
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