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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

KU-55933

HY-12016

(KU 55933; KU55933)

KU-55933

KU-55933 Chemical Structure

KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively; highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

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Free sample   Apply now  
10 mM * 1 mL in DMSO $68 In-stock
10 mg $62 In-stock
50 mg $198 In-stock
100 mg $352 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €67 In-stock
10 mg €61 In-stock
50 mg €194 In-stock
100 mg €345 In-stock
200 mg Get quote
500 mg Get quote

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Product name: KU-55933
Cat. No.: HY-12016

KU-55933 Data Sheet

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    Purity: 99.67%

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Biological Activity of KU-55933

KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively; highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
IC50 Value: 13 nM
Target: ATM
in vitro: KU-55933 inhibits DNA-PK and PI3K with IC50 of 2.5 μM and 16.6 μM, respectively. Besides, KU-55933 also prevents the activity of mTOR with IC50 of 9.3 μM. KU-55933 is active at the cellular level in ablating a well-characterized ATM-dependent phosphorylation event. KU-55933 has a dose-dependent effect in inhibiting this ATM-dependent phosphorylation event with IC50 of 300 nM. KU-58050 does not prevent the ATM-dependent phosphorylation of p53 serine 15 until a dose of 30 μM. Addition of KU-55933 has no appreciable effects on UV-induced phosphorylation of H2AX on serine 139, NBS1 on serine 343, CHK1 on serine 345, and SMC1 on serine 966. In stark contrast to the UV responses, KU-55933 ablates the ionizing radiation-induced phosphorylation of these ATM substrates. KU-55933 sensitizes HeLa cells to a range of ionizing radiation doses. KU-55933 inhibits the phosphorylation of Akt induced by growth factors in cancer cells. KU-55933 suppresses the proliferation of cancer cells. Furthermore, suppression of ATM by KU-55933 improves survival, probably via prevention of downstream activation of TAp63α.
in vivo: Suppression of ATM-dependent STAT3 activation by KU-55933 enhances TRAIL-mediated apoptosis through up-regulation of surface DR5 expression, whereas suppression of both STAT3 and NF-κB appeares to be involved in down-regulation of cFLIP accompanied by an additional increase in apoptotic levels. The ATM inhibitor KU-55933 affectes TRAIL-mediated apoptosis more strongly than the JAK2 inhibitor, AG490, or overexpression of STAT3β.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 395.49 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C21H17NO3S2
CAS No 587871-26-9
Solvent & Solubility

DMSO ≥48mg/mL Water <1.2mg/mL Ethanol ≥11mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.5285 mL 12.6425 mL 25.2851 mL
5 mM 0.5057 mL 2.5285 mL 5.0570 mL
10 mM 0.2529 mL 1.2643 mL 2.5285 mL

References on KU-55933

Inhibitor Kit

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