1. Metabolic Enzyme/Protease
    Membrane Transporter/Ion Channel
  2. HIF/HIF Prolyl-Hydroxylase
    ATP Synthase
  3. KUSC-5037


Cat. No.: HY-144750
Handling Instructions

KUSC-5037 is a potent HIF-1 inhibitor (IC50=1.2 μM). KUSC-5037 inhibits mitochondrial respiratory complex V and FoF1-ATP synthase.

For research use only. We do not sell to patients.

KUSC-5037 Chemical Structure

KUSC-5037 Chemical Structure

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KUSC-5037 is a potent HIF-1 inhibitor (IC50=1.2 μM). KUSC-5037 inhibits mitochondrial respiratory complex V and FoF1-ATP synthase[1].

In Vitro

Under hypoxic conditions, KUSC-5037 suppresses the HIF-1α mRNA, causing decreases in the gene expression of HIF-1 target genes such as carbonic anhydrase 9 (CA9) and vascular endothelial growth factor (VEGF) genes[1].
KUSC-5037 exhibits cell growth inhibitory activity with IC50 values of 34.5 μM and 0.6 μM against human cervical cancer HeLa S3 cells and fibrosarcoma HT1080 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight





Room temperature in continental US; may vary elsewhere.


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