1. Metabolic Enzyme/Protease
    Membrane Transporter/Ion Channel
  2. HIF/HIF Prolyl-Hydroxylase
    ATP Synthase
  3. KUSC-5037

KUSC-5037 

Cat. No.: HY-144750
Handling Instructions

KUSC-5037 is a potent HIF-1 inhibitor (IC50=1.2 μM). KUSC-5037 inhibits mitochondrial respiratory complex V and FoF1-ATP synthase.

For research use only. We do not sell to patients.

KUSC-5037 Chemical Structure

KUSC-5037 Chemical Structure

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Description

KUSC-5037 is a potent HIF-1 inhibitor (IC50=1.2 μM). KUSC-5037 inhibits mitochondrial respiratory complex V and FoF1-ATP synthase[1].

In Vitro

Under hypoxic conditions, KUSC-5037 suppresses the HIF-1α mRNA, causing decreases in the gene expression of HIF-1 target genes such as carbonic anhydrase 9 (CA9) and vascular endothelial growth factor (VEGF) genes[1].
KUSC-5037 exhibits cell growth inhibitory activity with IC50 values of 34.5 μM and 0.6 μM against human cervical cancer HeLa S3 cells and fibrosarcoma HT1080 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

406.36

Formula

C18H17F3N6O2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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Product Name:
KUSC-5037
Cat. No.:
HY-144750
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